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Study · Randomized controlled trial · n = 70 · 2019

3 results

Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study).

Makino H, Tanaka A, Asakura K, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Son C, Shimabara Y, Fujita T, Miyamoto Y, Kobayashi J, Hosoda K

Diabetic medicine : a journal of the British Diabetic Association2 Aug 2019Cited by 16 (Europe PMC)

PMID31335979 (opens in a new tab)DOI10.1111/dme.14084 (opens in a new tab)PepBankPUB-31335979
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, adding liraglutide to insulin gave a lower average M value than insulin alone.

    In plain wordsIn adults with type 2 diabetes having heart surgery, adding liraglutide to insulin gave blood glucose closer to target than insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseAverage M value (glycaemic control)
    Study

    n = 70

    Comparator
    Insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.6 mg/dayAs given in this study (human).

    Measurements

    Average M value
    5.8
    liraglutide plus insulin
    Average M value
    12.3
    insulin alone

    Source sentences

    Summary
    The average M value in the liraglutide plus insulin group was significantly lower than that in the insulin-alone group (liraglutide plus insulin 5.8 vs insulin-alone 12.3; P < 0.001).
    2 context sentences
    Summary · context
    We studied 70 people with Type 2 diabetes who underwent elective cardiac surgery.
    Summary · context
    Participants were randomized to either an insulin-alone or an insulin plus liraglutide 0.6 mg/day group.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, insulin dose modification was less frequent with liraglutide plus insulin than with insulin alone.

    In plain wordsIn adults with type 2 diabetes having heart surgery, insulin doses needed changing less often with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseFrequency of insulin dose modification
    Study

    n = 70

    Comparator
    Insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.6 mg/dayAs given in this study (human).

    Source sentences

    Summary
    The frequency of insulin dose modification in the liraglutide plus insulin group was significantly lower than that in the insulin-alone group (odds ratio 0.19, 95% CI 0.08-0.49; P < 0.001).
    2 context sentences
    Summary · context
    We studied 70 people with Type 2 diabetes who underwent elective cardiac surgery.
    Summary · context
    Participants were randomized to either an insulin-alone or an insulin plus liraglutide 0.6 mg/day group.
  3. 03HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing cardiac surgery, hypoglycaemia tended to be less frequent with liraglutide plus insulin than with insulin alone, but the difference was not significant.

    In plain wordsIn adults with type 2 diabetes having heart surgery, low blood sugar tended to occur less often with liraglutide plus insulin, not significantly.

    Peptide
    Liraglutide
    Outcome
    No significant changeFrequency of hypoglycaemia
    Study

    n = 70

    Comparator
    Insulin alone
    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    0.6 mg/dayAs given in this study (human).

    Source sentences

    Summary
    The frequency of hypoglycaemia in the liraglutide plus insulin group tended to be lower than that in the insulin-alone group (odds ratio 0.57, 95% CI 0.15-2.23; P = 0.21).
    2 context sentences
    Summary · context
    We studied 70 people with Type 2 diabetes who underwent elective cardiac surgery.
    Summary · context
    Participants were randomized to either an insulin-alone or an insulin plus liraglutide 0.6 mg/day group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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