Study · Animal study (in vivo) · rat · 2019
11 resultsLiu L, Wang Q, Zhao B, Wu Q, Wang P
European journal of pharmacology3 Jul 2019Cited by 43 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
11 results from studies that gave the peptide. No result from this study comes from people.
In rats, NAD treatment increased myocardial total NAD levels.
In plain wordsIn rats, NAD treatment increased total NAD levels in the heart.
ratn: not reported in source
Rat myocardiumSource sentences
We first found that myocardial total NAD level was remarkably increased with NAD treatment (10 mg/kg) for 14 days.
In isolated rat hearts, NAD administration decreased coronary leakage LDH levels.
In plain wordsIn lab tests with rat hearts, NAD decreased LDH in coronary leakage.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
NAD administration significantly decreased the lactate dehydrogenase (LDH) level in coronary leakage, decreased the malondialdehyde (MDA) level and increased the reduced glutathione/oxidized glutathione disulfide ratio (GSH/GSSG) in myocardial tissue.
In rat myocardial tissue, NAD administration decreased MDA levels.
In plain wordsIn lab tests with rat heart tissue, NAD decreased MDA levels.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
NAD administration significantly decreased the lactate dehydrogenase (LDH) level in coronary leakage, decreased the malondialdehyde (MDA) level and increased the reduced glutathione/oxidized glutathione disulfide ratio (GSH/GSSG) in myocardial tissue.
In rat myocardial tissue, NAD administration increased the GSH/GSSG ratio.
In plain wordsIn lab tests with rat heart tissue, NAD increased the GSH/GSSG ratio.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
NAD administration significantly decreased the lactate dehydrogenase (LDH) level in coronary leakage, decreased the malondialdehyde (MDA) level and increased the reduced glutathione/oxidized glutathione disulfide ratio (GSH/GSSG) in myocardial tissue.
In isolated rat hearts after ischemia-reperfusion, NAD attenuated cardiac function depression.
In plain wordsIn lab tests with rat hearts, NAD reduced loss of cardiac function after ischemia-reperfusion.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
In addition, NAD treatment effectively attenuated the depression of cardiac function in the isolated rat hearts after ischemia-reperfusion.
In rat hearts, NAD attenuated succinate accumulation during ischemia.
In plain wordsIn lab tests with rat hearts, NAD reduced succinate accumulation during ischemia.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
Furthermore, we found that exogenous NAD attenuated the succinate accumulation during ischemia and decreased its depleting rate during reperfusion.
In rat hearts, NAD decreased succinate depletion rate during reperfusion.
In plain wordsIn lab tests with rat hearts, NAD slowed succinate depletion during reperfusion.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
Furthermore, we found that exogenous NAD attenuated the succinate accumulation during ischemia and decreased its depleting rate during reperfusion.
In rat myocardium, NAD had no obvious effect on Sirt5 expression.
In plain wordsIn lab tests with rat heart tissue, NAD had no obvious effect on Sirt5 expression.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
We also found that NAD administration had no obvious effects on myocardial Sirt5 and SDH-a expressions.
In rat myocardium, NAD had no obvious effect on SDH-a expression.
In plain wordsIn lab tests with rat heart tissue, NAD had no obvious effect on SDH-a expression.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
We also found that NAD administration had no obvious effects on myocardial Sirt5 and SDH-a expressions.
In rat myocardium, NAD promoted the interaction of Sirt5 and SDH-a.
In plain wordsIn lab tests with rat heart tissue, NAD increased the interaction of Sirt5 and SDH-a.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
Utilizing co-immunoprecipitation method, we found that NAD administration promoted the Sirt5 and SDH-a interaction and decreased the succinylation level of SDH-a.
In rat myocardium, NAD decreased SDH-a succinylation.
In plain wordsIn lab tests with rat heart tissue, NAD decreased SDH-a succinylation.
ratn: not reported in source
Isolated ischemia-reperfused rat heartsSource sentences
Utilizing co-immunoprecipitation method, we found that NAD administration promoted the Sirt5 and SDH-a interaction and decreased the succinylation level of SDH-a.
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14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC
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