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Study · Animal study (in vivo) · rat · 2019

3 results

Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31.

Czigler A, Toth L, Szarka N, Berta G, Amrein K, Czeiter E, Lendvai-Emmert D, Bodo K, Tarantini S, Koller A, Ungvari Z, Buki A, Toth P

Journal of neurotrauma1 Aug 2019Cited by 24 (Europe PMC)

PMID31266393 (opens in a new tab)PMCIDPMC6857460 (opens in a new tab)DOI10.1089/neu.2019.6439 (opens in a new tab)PepBankPUB-31266393
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats with mild TBI, SS‑31 reversed the increase in cytoplasmic superoxide production in middle cerebral arteries to the normal level.

    In plain wordsIn hypertensive rats with mild brain injury, SS‑31 brought cytoplasmic oxidative stress in brain arteries back to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCytoplasmic superoxide production in middle cerebral arteries
    Study

    ratn: not reported in source

    Spontaneously hypertensive rats (SHR) after mild TBI
    Comparator
    Untreated mTBI SHR
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    5.7 mg/kg per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    mTBI induced a significant increase in long-term cytoplasmic and mitochondrial O2- production in MCAs of SHRs and increased expression of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit Nox4, which were reversed to the normal level by treating the animals with the…
    1 context sentence
    Summary · context
    we induced mTBI in normotensive and spontaneously hypertensive rats (SHR)
  2. 02AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats with mild TBI, SS‑31 reversed the increase in mitochondrial superoxide production in middle cerebral arteries to the normal level.

    In plain wordsIn hypertensive rats with mild brain injury, SS‑31 brought mitochondrial oxidative stress in brain arteries back to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial superoxide production in middle cerebral arteries
    Study

    ratn: not reported in source

    Spontaneously hypertensive rats (SHR) after mild TBI
    Comparator
    Untreated mTBI SHR
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    5.7 mg/kg per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    mTBI induced a significant increase in long-term cytoplasmic and mitochondrial O2- production in MCAs of SHRs and increased expression of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit Nox4, which were reversed to the normal level by treating the animals with the…
    1 context sentence
    Summary · context
    we induced mTBI in normotensive and spontaneously hypertensive rats (SHR)
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats with mild TBI, SS‑31 reversed the increase in NADPH oxidase subunit Nox4 expression to the normal level.

    In plain wordsIn hypertensive rats with mild brain injury, SS‑31 brought the level of an oxidative stress enzyme subunit back to normal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNox4 expression in middle cerebral arteries
    Study

    ratn: not reported in source

    Spontaneously hypertensive rats (SHR) after mild TBI
    Comparator
    Untreated mTBI SHR
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    5.7 mg/kg per day · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    mTBI induced a significant increase in long-term cytoplasmic and mitochondrial O2- production in MCAs of SHRs and increased expression of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit Nox4, which were reversed to the normal level by treating the animals with the…
    1 context sentence
    Summary · context
    we induced mTBI in normotensive and spontaneously hypertensive rats (SHR)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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