Chivosazole A bound to actin inhibited the interaction of G-actin with thymosin-β4, together with gelsolin, profilin and cofilin.
In plain wordsIn lab tests, the compound chivosazole A blocked actin from binding thymosin-β4. The study tested the compound, not thymosin-β4 as a treatment.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- DecreaseInteraction of G-actin with thymosin-β4 in the presence of chivosazole A
- Study
n: not reported in source
Actin with chivosazole A (crystal structure and binding assays)- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
interaction with gelsolin, profilin, cofilin, and thymosin-β4 is inhibited.
1 context sentence(design, population, supporting numbers)
We provide a crystal structure of the natural product chivosazole A (ChivoA) bound to actin and show that-in addition to inhibiting nucleation, polymerization, and severing of F-actin filaments-it selectively modulates binding of ABPs to G-actin: Although unphysiological actin dimers are induced by…
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).