Skip to content

Study · Animal study (in vivo) · mouse · 2019

3 results

Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice.

Abplanalp W, Haberzettl P, Bhatnagar A, Conklin DJ, O'Toole TE

Journal of the American Heart Association25 Jun 2019Cited by 24 (Europe PMC)

PMID31234700 (opens in a new tab)PMCIDPMC6662354 (opens in a new tab)DOI10.1161/jaha.119.013041 (opens in a new tab)PepBankPUB-31234700
Read at sourcePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In particle-exposed mice, carnosine significantly attenuated bone marrow hematopoietic stem cell depletion.

    In plain wordsIn particle-exposed mice, carnosine reduced bone marrow blood stem cell depletion compared with normal drinking water.

    Peptide
    L-carnosine
    Outcome
    DecreaseHematopoietic stem cell depletion
    Study

    mousen: not reported in source

    Concentrated ambient particle-exposed mice
    Comparator
    Normal drinking water during concentrated ambient particle exposure
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    However, HSC depletion was significantly attenuated when the mice were placed on drinking water containing carnosine.
    1 context sentence
    Summary · context
    Methods and Results Mice given normal drinking water or that supplemented with carnosine, a naturally occurring, nucleophilic di-peptide that binds reactive aldehydes, were exposed to filtered air or concentrated ambient particles.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In particle-exposed mice, carnosine increased urinary carnosine-propanal conjugates.

    In plain wordsIn particle-exposed mice, carnosine increased urinary carnosine-propanal conjugates compared with normal drinking water.

    Peptide
    L-carnosine
    Outcome
    IncreaseUrinary carnosine-propanal conjugates
    Study

    mousen: not reported in source

    Concentrated ambient particle-exposed mice
    Comparator
    Normal drinking water during concentrated ambient particle exposure
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine supplementation also increased the levels of carnosine-propanal conjugates in the urine of CAPs-exposed mice and prevented the concentrated ambient particles-induced dysfunction of endothelial progenitor cells as assessed by in vitro and in vivo assays.
    1 context sentence
    Summary · context
    Methods and Results Mice given normal drinking water or that supplemented with carnosine, a naturally occurring, nucleophilic di-peptide that binds reactive aldehydes, were exposed to filtered air or concentrated ambient particles.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In particle-exposed mice, carnosine prevented endothelial progenitor cell dysfunction assessed with in vitro and in vivo assays.

    In plain wordsIn particle-exposed mice, carnosine prevented endothelial progenitor cell dysfunction compared with normal drinking water.

    Peptide
    L-carnosine
    Outcome
    DecreaseEndothelial progenitor cell dysfunction
    Study

    mousen: not reported in source

    Concentrated ambient particle-exposed mice
    Comparator
    Normal drinking water during concentrated ambient particle exposure
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    Carnosine supplementation also increased the levels of carnosine-propanal conjugates in the urine of CAPs-exposed mice and prevented the concentrated ambient particles-induced dysfunction of endothelial progenitor cells as assessed by in vitro and in vivo assays.
    1 context sentence
    Summary · context
    Methods and Results Mice given normal drinking water or that supplemented with carnosine, a naturally occurring, nucleophilic di-peptide that binds reactive aldehydes, were exposed to filtered air or concentrated ambient particles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.