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Study · Animal study (in vivo) · mouse · 2020

4 results

Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.

Celvin B, Zaman F, Aulin C, Sävendahl L

Clinical and experimental rheumatology6 Jun 2019Cited by 14 (Europe PMC)

PMID31172921 (opens in a new tab)PepBankPUB-31172921
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagen-induced arthritis, adding HNG to dexamethasone protected articular cartilage from dexamethasone-induced chondrocyte apoptosis.

    In plain wordsIn mice with arthritis, adding HNG to dexamethasone protected joint cartilage cells from cell death.

    Peptide
    Humanin
    Outcome
    DecreaseDexamethasone-induced chondrocyte apoptosis in articular cartilage
    Study

    micen: not reported in source

    Collagen-induced arthritis in DBA/1 mice
    Comparator
    Dexamethasone alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 μg/kg/day · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    We found that HNG treatment in combination with Dexa protected from Dexa-induced chondrocyte apoptosis in both articular and growth plate cartilage.
    1 context sentence
    Summary · context
    Arthritis was induced in DBA/1 mice by collagen type II in complete Freund's adjuvant and the animals were treated with Dexamethasone (Dexa) (0.25 mg/kg/day) with or without HNG (100 μg/kg/day) for 14 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagen-induced arthritis, adding HNG to dexamethasone protected growth plate cartilage from dexamethasone-induced chondrocyte apoptosis.

    In plain wordsIn mice with arthritis, adding HNG to dexamethasone protected growth plate cartilage cells from cell death.

    Peptide
    Humanin
    Outcome
    DecreaseDexamethasone-induced chondrocyte apoptosis in growth plate cartilage
    Study

    micen: not reported in source

    Collagen-induced arthritis in DBA/1 mice
    Comparator
    Dexamethasone alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 μg/kg/day · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    We found that HNG treatment in combination with Dexa protected from Dexa-induced chondrocyte apoptosis in both articular and growth plate cartilage.
    1 context sentence
    Summary · context
    Arthritis was induced in DBA/1 mice by collagen type II in complete Freund's adjuvant and the animals were treated with Dexamethasone (Dexa) (0.25 mg/kg/day) with or without HNG (100 μg/kg/day) for 14 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagen-induced arthritis, HNG did not interfere with the anti-inflammatory effect of dexamethasone on clinical scoring.

    In plain wordsIn mice with arthritis, HNG did not block the anti-inflammatory effect of dexamethasone on clinical scores.

    Peptide
    Humanin
    Outcome
    No significant changeAnti-inflammatory effect of dexamethasone, clinical scoring
    Study

    micen: not reported in source

    Collagen-induced arthritis in DBA/1 mice
    Comparator
    Dexamethasone alone
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    100 μg/kg/day · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Furthermore, based on clinical and histology scoring analyses, HNG did not interfere with the desired anti-inflammatory effect of Dexa.
    1 context sentence
    Summary · context
    Arthritis was induced in DBA/1 mice by collagen type II in complete Freund's adjuvant and the animals were treated with Dexamethasone (Dexa) (0.25 mg/kg/day) with or without HNG (100 μg/kg/day) for 14 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with collagen-induced arthritis, HNG did not interfere with the anti-inflammatory effect of dexamethasone on histology scoring.

    In plain wordsIn mice with arthritis, HNG did not block the anti-inflammatory effect of dexamethasone on joint tissue scores.

    Peptide
    Humanin
    Outcome
    No significant changeAnti-inflammatory effect of dexamethasone, histology scoring
    Study

    micen: not reported in source

    Collagen-induced arthritis in DBA/1 mice
    Comparator
    Dexamethasone alone
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    100 μg/kg/day · 14 daysAs given in this study (mice).

    Source sentences

    Summary
    Furthermore, based on clinical and histology scoring analyses, HNG did not interfere with the desired anti-inflammatory effect of Dexa.
    1 context sentence
    Summary · context
    Arthritis was induced in DBA/1 mice by collagen type II in complete Freund's adjuvant and the animals were treated with Dexamethasone (Dexa) (0.25 mg/kg/day) with or without HNG (100 μg/kg/day) for 14 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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