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Study · In vitro (cells) · rat · 2019

3 results

Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.

Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z

GeroScience29 May 2019Cited by 121 (Europe PMC)

PMID31144244 (opens in a new tab)PMCIDPMC6885080 (opens in a new tab)DOI10.1007/s11357-019-00074-2 (opens in a new tab)PepBankPUB-31144244
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In aged rat cerebromicrovascular endothelial cells, NMN significantly improved angiogenic processes.

    In plain wordsIn cells from aged rats, NMN significantly improved blood vessel formation processes.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAngiogenic processes
    Study

    ratn: not reported in source

    Cerebromicrovascular endothelial cells isolated from aged F344xBN rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment in aged CMVECs significantly improved angiogenic processes and attenuated H2O2 production.
  2. 02LabIn vitro (cells)Mechanism

    In aged rat cerebromicrovascular endothelial cells, NMN attenuated hydrogen peroxide production.

    In plain wordsIn cells from aged rats, NMN reduced hydrogen peroxide production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseHydrogen peroxide production
    Study

    ratn: not reported in source

    Cerebromicrovascular endothelial cells isolated from aged F344xBN rats
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN treatment in aged CMVECs significantly improved angiogenic processes and attenuated H2O2 production.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 03LabNot a test of NMN (nicotinamide mononucleotide) aloneIn vitro (cells)Mechanism

    In aged rat endothelial cells, SIRT1 inhibitor EX-527 prevented NMN-mediated restoration of angiogenic processes.

    In plain wordsIn cells from aged rats, EX-527 blocked NMN-mediated restoration of blood vessel formation processes.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSIRT1 dependence of angiogenic restoration
    Study

    ratn: not reported in source

    Cerebromicrovascular endothelial cells isolated from aged F344xBN rats
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    We also found that pre-treatment with EX-527, a pharmacological inhibitor of SIRT1, prevented NMN-mediated restoration of angiogenic processes in aged CMVECs.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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