Skip to content

Study · Not a test of the peptide alone · 2019

2 results

Carnosine induces intestinal cells to secrete exosomes that activate neuronal cells.

Sugihara Y, Onoue S, Tashiro K, Sato M, Hasegawa T, Katakura Y

PloS one28 May 2019Cited by 28 (Europe PMC)

PMID31136600 (opens in a new tab)PMCIDPMC6538158 (opens in a new tab)DOI10.1371/journal.pone.0217394 (opens in a new tab)PepBankPUB-31136600
Download PDFPubMedAsk about this study
Jump to 2 results

Summary

Recently, we showed that imidazole dipeptide such as carnosine contained abundantly in chicken breast meat improves brain function in a double-blind randomized controlled trial. However, the underlying molecular mechanisms remain unknown. Here, we investigated whether carnosine activates intestinal epithelial cells and induces the secretion of factors that activate brain function. We focused on exosomes derived from intestinal epithelial cells as mediators of brain-gut interaction. Results showed that exosomes derived from Caco-2 cells treated with carnosine significantly induced neurite growth in SH-SY5Y cells. To clarify the molecular basis of this finding, we performed integrated analysis of microRNAs (miRNAs) with altered expression in exosomes in response to carnosine treatment and mRNAs with altered expression in target cells in response to exosome treatment to identify related miRNAs and their target genes. The combination of miR-6769-5p and its target gene ATXN1 was found to be involved in the exosome-induced activation of neuronal cells.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

  1. 01LabNot a test of L-carnosine aloneIn vitro (cells)Mechanism

    In SH-SY5Y cells, exosomes from carnosine-treated Caco-2 cells significantly induced neurite growth.

    In plain wordsIn cells, exosomes from carnosine-treated intestinal cells significantly induced nerve extension growth.

    Peptide
    L-carnosine
    Outcome
    IncreaseNeurite growth
    Study

    humann: not reported in source

    Caco-2-derived exosomes and SH-SY5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Results showed that exosomes derived from Caco-2 cells treated with carnosine significantly induced neurite growth in SH-SY5Y cells.
    2 context sentences
    Summary · context
    Here, we investigated whether carnosine activates intestinal epithelial cells and induces the secretion of factors that activate brain function.
    Summary · context
    We focused on exosomes derived from intestinal epithelial cells as mediators of brain-gut interaction.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

  2. 02LabNot a test of L-carnosine aloneIn vitro (cells)Mechanism

    In the carnosine-conditioned exosome model, miR-6769-5p and ATXN1 were involved in exosome-induced neuronal activation.

    In plain wordsIn cells, miR-6769-5p and ATXN1 were involved in neuronal activation induced by exosomes from carnosine-treated cells.

    Peptide
    L-carnosine
    Outcome
    Not applicablemiR-6769-5p and ATXN1 involvement
    Study

    humann: not reported in source

    Caco-2-derived exosomes and SH-SY5Y cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The combination of miR-6769-5p and its target gene ATXN1 was found to be involved in the exosome-induced activation of neuronal cells.
    3 context sentences
    Summary · context
    To clarify the molecular basis of this finding, we performed integrated analysis of microRNAs (miRNAs) with altered expression in exosomes in response to carnosine treatment and mRNAs with altered expression in target cells in response to exosome treatment to identify related miRNAs and their target genes.
    Summary · context
    Here, we investigated whether carnosine activates intestinal epithelial cells and induces the secretion of factors that activate brain function.
    Summary · context
    We focused on exosomes derived from intestinal epithelial cells as mediators of brain-gut interaction.

    In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.