Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.

Avcil M, Akman G, Klokkers J, Jeong D, Çelik A

Journal of cosmetic dermatology28 May 2019Cited by 34 (Europe PMC)

PMID31134751DOI10.1111/jocd.13009PepBankPUB-31134751

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking SNAP-8 (acetyl octapeptide-3).

01HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialSafety outcome
In healthy subjects with aged skin, no primary or cumulative skin reactions were reported with the multi-ingredient HA-MNs.
In plain wordsIn healthy subjects with aged skin, no primary or cumulative skin reactions were reported with the multi-ingredient HA-MNs.
Peptide
SNAP-8 (acetyl octapeptide-3)
Outcome
Not applicablePrimary and cumulative skin reactions
Study
n: not reported in source
Outcome group
Adverse events · Skin and wound
Source sentences
Summary
The product was tolerated excellently; none of the subjects reported any primary or cumulative skin reactions.
2 context sentences(design, population, supporting numbers)
Summary · context
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts.
Summary · context
In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).
Report a problemFND-3113475101
02HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome
In healthy subjects with aged skin, multi-ingredient HA-MNs decreased fine lines and wrinkles by 25.8%.
In plain wordsIn healthy subjects with aged skin, multi-ingredient HA-MNs reduced fine lines and wrinkles by 25.8%.
Peptide
SNAP-8 (acetyl octapeptide-3)
Outcome
DecreaseFine lines and wrinkles
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Fine lines/wrinkles decrease
25.8%
HA-MNs
Source sentences
Summary
The fine lines/wrinkles showed 25.8% noticeable decrease;
2 context sentences(design, population, supporting numbers)
Summary · context
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts.
Summary · context
In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).
Report a problemFND-3113475103
03HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome
In healthy subjects with aged skin, multi-ingredient HA-MNs improved skin hydration by 15.4%.
In plain wordsIn healthy subjects with aged skin, multi-ingredient HA-MNs improved skin hydration by 15.4%.
Peptide
SNAP-8 (acetyl octapeptide-3)
Outcome
IncreaseSkin hydration
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Skin hydration improvement
15.4%
HA-MNs
Source sentences
Summary
the skin hydration measurements demonstrated 15.4% improvement;
2 context sentences(design, population, supporting numbers)
Summary · context
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts.
Summary · context
In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).
Report a problemFND-3113475104
04HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome
In healthy subjects with aged skin, multi-ingredient HA-MNs increased dermal density by 14.2%.
In plain wordsIn healthy subjects with aged skin, multi-ingredient HA-MNs increased dermal density by 14.2%.
Peptide
SNAP-8 (acetyl octapeptide-3)
Outcome
IncreaseDermal density
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Dermal density increase
14.2%
HA-MNs
Source sentences
Summary
the skin density and thickness in the dermis increased 14.2% and 12.9%, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts.
Summary · context
In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).
Report a problemFND-3113475105
05HumanNot a test of SNAP-8 (acetyl octapeptide-3) aloneNon-randomized trialEfficacy outcome
In healthy subjects with aged skin, multi-ingredient HA-MNs increased dermal thickness by 12.9%.
In plain wordsIn healthy subjects with aged skin, multi-ingredient HA-MNs increased dermal thickness by 12.9%.
Peptide
SNAP-8 (acetyl octapeptide-3)
Outcome
IncreaseDermal thickness
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Dermal thickness increase
12.9%
HA-MNs
Source sentences
Summary
the skin density and thickness in the dermis increased 14.2% and 12.9%, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The test product of HA-MNs comprises arginine/lysine polypeptide, acetyl octapeptide-3, palmitoyl tripeptide-5, adenosine, and seaweed extracts.
Summary · context
In the monocentric 12-week clinical trial, the HA-MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin.
In this study, SNAP-8 (acetyl octapeptide-3) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SNAP-8 (acetyl octapeptide-3).
Report a problemFND-3113475106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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