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Study · Animal study (in vivo) · rat · 2019

4 results

Protective Effect of Thymosin β4 against Abdominal Aortic Ischemia-Reperfusion-Induced Acute Lung Injury in Rats.

Yaman OM, Guner I, Guntas G, Sonmez OF, Tanriverdi G, Cakiris A, Aksu U, Akyol S, Guzel E, Uzun H, Yelmen N, Sahin G

Medicina (Kaunas, Lithuania)22 May 2019Cited by 11 (Europe PMC)

PMID31121838 (opens in a new tab)PMCIDPMC6572620 (opens in a new tab)DOI10.3390/medicina55050187 (opens in a new tab)PepBankPUB-31121838
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Summary

Background and objectives: Ischemia-reperfusion (IR) caused by infrarenal abdominal aorta cross-clamping is an important factor in the development of ischemia-reperfusion injury in various distant organs. Materials and Methods: We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR. Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods. One group received Tβ4 1 h before ischemia, and the other received 15 min before the reperfusion period. Results: Results were compared to control and non-Tβ4-treated rats with IR. Serum, bronchoalveolar lavage fluid and lung tissue levels of oxidant parameters were higher, while antioxidant levels were lower in the IR group compared to control. IR also increased inflammatory cytokine levels. Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group. Conclusions: Since there is no statistical difference between the prescribed results of both Tβ4-treated groups, our study demonstrates that Tβ4 reduced lung oxidative stress and inflammation following IR and prevented lung tissue injury regardless of timing of administration.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with abdominal aortic ischemia-reperfusion, Tβ4 reverted the raised oxidant parameters in serum, bronchoalveolar lavage fluid and lung tissue compared with untreated IR.

    In plain wordsIn rats with induced ischemia-reperfusion, thymosin beta‑4 reversed the rise in oxidant markers in blood and lung compared with untreated rats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseOxidant parameters in serum, BALF and lung tissue
    Study

    ratn: not reported in source

    Abdominal aortic ischemia-reperfusion (IR) with lung injury
    Comparator
    Untreated IR group
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    10 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Serum, bronchoalveolar lavage fluid and lung tissue levels of oxidant parameters were higher, while antioxidant levels were lower in the IR group compared to control. IR also increased inflammatory cytokine levels. Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group.
    2 context sentences
    Summary · context
    We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR.
    Summary · context
    Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with abdominal aortic ischemia-reperfusion, Tβ4 reverted the lowered antioxidant levels in serum, bronchoalveolar lavage fluid and lung tissue compared with untreated IR.

    In plain wordsIn rats with induced ischemia-reperfusion, thymosin beta‑4 reversed the fall in antioxidant levels in blood and lung compared with untreated rats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAntioxidant levels in serum, BALF and lung tissue
    Study

    ratn: not reported in source

    Abdominal aortic ischemia-reperfusion (IR) with lung injury
    Comparator
    Untreated IR group
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    10 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Serum, bronchoalveolar lavage fluid and lung tissue levels of oxidant parameters were higher, while antioxidant levels were lower in the IR group compared to control. IR also increased inflammatory cytokine levels. Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group.
    2 context sentences
    Summary · context
    We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR.
    Summary · context
    Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with abdominal aortic ischemia-reperfusion, Tβ4 reverted the increased inflammatory cytokine levels compared with untreated IR.

    In plain wordsIn rats with induced ischemia-reperfusion, thymosin beta‑4 reversed the rise in inflammation markers compared with untreated rats.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInflammatory cytokine levels
    Study

    ratn: not reported in source

    Abdominal aortic ischemia-reperfusion (IR) with lung injury
    Comparator
    Untreated IR group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    IR also increased inflammatory cytokine levels. Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group.
    2 context sentences
    Summary · context
    We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR.
    Summary · context
    Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with abdominal aortic ischemia-reperfusion, the two Tβ4 timing groups showed no statistical difference in the parameters measured.

    In plain wordsIn rats with induced ischemia-reperfusion, thymosin beta‑4 worked about equally well when given before ischemia or before reperfusion.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeTiming of Tβ4 administration (1 h before ischemia vs 15 min before reperfusion)
    Study

    ratn: not reported in source

    Abdominal aortic ischemia-reperfusion (IR) with lung injury
    Comparator
    Tβ4 given at the other time point
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    10 mg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Since there is no statistical difference between the prescribed results of both Tβ4-treated groups
    3 context sentences
    Summary · context
    One group received Tβ4 1 h before ischemia, and the other received 15 min before the reperfusion period.
    Summary · context
    We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR.
    Summary · context
    Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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