Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being.

Guaitolini E, Cavezzi A, Cocchi S, Colucci R, Urso SU, Quinzi V

The Journal of clinical and aesthetic dermatology1 Apr 2019Cited by 5 (Europe PMC)

PMID31119010PMCIDPMC6508480PepBankPUB-31119010

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

01HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased glabella hydration by 15.2 percent after 60 days.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased glabella hydration from baseline.
Peptide
L-carnosine
Outcome
IncreaseGlabella hydration
Study
n = 25
Comparator
Baseline; no significant variation in the placebo group
Outcome group
Skin and hair · Skin and wound
Measurements
glabella skin hydration increase
15.2%
multicomponent nutraceutical group, day 60 versus day 0
Source sentences
Summary
After 60 days of MCN intake, glabella skin hydration and elasticity improved by 15.2 percent and 22.6 percent, respectively (p=0.03; p=0.004),
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901001
02HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased glabella elasticity by 22.6 percent after 60 days.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased glabella elasticity from baseline.
Peptide
L-carnosine
Outcome
IncreaseGlabella elasticity
Study
n = 25
Comparator
Baseline; no significant variation in the placebo group
Outcome group
Skin and hair · Skin and wound
Measurements
glabella skin elasticity increase
22.6%
multicomponent nutraceutical group, day 60 versus day 0
Source sentences
Summary
After 60 days of MCN intake, glabella skin hydration and elasticity improved by 15.2 percent and 22.6 percent, respectively (p=0.03; p=0.004),
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901002
03HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical decreased glabella sebaceous secretion by 24.2 percent.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical decreased glabella sebaceous secretion from baseline.
Peptide
L-carnosine
Outcome
DecreaseGlabella sebaceous secretion
Study
n = 25
Comparator
Baseline; no significant variation in the placebo group
Outcome group
Skin and hair · Skin and wound
Measurements
glabella sebaceous secretion decrease
24.2%
multicomponent nutraceutical group, day 60 versus day 0
Source sentences
Summary
glabella sebaceous secretion decreased by 24.2 percent (p=0.01),
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901003
04HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased periocular hydration by 12.6 percent.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased periocular hydration from baseline.
Peptide
L-carnosine
Outcome
IncreasePeriocular hydration
Study
n = 25
Comparator
Baseline; no significant variation in the placebo group
Outcome group
Skin and hair · Skin and wound
Measurements
periocular skin hydration increase
12.6%
multicomponent nutraceutical group, day 60 versus day 0
Source sentences
Summary
skin hydration and elasticity of the periocular area increased by 12.6 percent and 15.9 percent, respectively,
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901004
05HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased periocular elasticity by 15.9 percent.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased periocular elasticity from baseline.
Peptide
L-carnosine
Outcome
IncreasePeriocular elasticity
Study
n = 25
Outcome group
Skin and hair · Skin and wound
Measurements
Periocular elasticity change
15.9 percent
MCN group, day 60 versus baseline
Source sentences
Summary
skin hydration and elasticity of the periocular area increased by 12.6 percent and 15.9 percent, respectively,
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901005
06HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased oral commissural hydration by 17.6 percent.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased oral commissural hydration from baseline.
Peptide
L-carnosine
Outcome
IncreaseOral commissural hydration
Study
n = 25
Outcome group
Skin and hair · Skin and wound
Measurements
Oral commissural hydration change
17.6 percent
MCN group, day 60 versus baseline
Source sentences
Summary
and skin hydration and elasticity of the oral commissural area increased by 17.6 percent and 16 percent, respectively (p<0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901006
07HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical increased oral commissural elasticity by 16 percent.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical increased oral commissural elasticity from baseline.
Peptide
L-carnosine
Outcome
IncreaseOral commissural elasticity
Study
n = 25
Outcome group
Skin and hair · Skin and wound
Measurements
Oral commissural elasticity change
16 percent
MCN group, day 60 versus baseline
Source sentences
Summary
and skin hydration and elasticity of the oral commissural area increased by 17.6 percent and 16 percent, respectively (p<0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901007
08HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, the multicomponent nutraceutical slightly improved wrinkle depth, unlike placebo.
In plain wordsIn women with facial photoaging, the multicomponent nutraceutical slightly improved wrinkle depth, unlike placebo.
Peptide
L-carnosine
Outcome
DecreaseWrinkle depth
Study
n = 25
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Wrinkle depth improved slightly in the MCN group (p=0.043 in the periocular area) but not in the placebo group.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901008
09HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in joint pain.
In plain wordsIn women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in joint pain.
Peptide
L-carnosine
Outcome
DecreaseJoint pain
Study
n = 25
Comparator
placebo
Outcome group
Pain · Musculoskeletal
Source sentences
Summary
A slight improvement in joint pain and mucosae/ hair appearance was reported in the questionnaire in the MCN group only.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901009
10HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in mucosae appearance.
In plain wordsIn women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in mucosae appearance.
Peptide
L-carnosine
Outcome
IncreaseMucosae appearance
Study
n = 25
Comparator
placebo
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
A slight improvement in joint pain and mucosae/ hair appearance was reported in the questionnaire in the MCN group only.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901010
11HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in hair appearance.
In plain wordsIn women with facial photoaging, only the multicomponent nutraceutical group reported slight improvement in hair appearance.
Peptide
L-carnosine
Outcome
IncreaseHair appearance
Study
n = 25
Comparator
placebo
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
A slight improvement in joint pain and mucosae/ hair appearance was reported in the questionnaire in the MCN group only.
2 context sentences(design, population, supporting numbers)
Summary · context
A randomized, placebo-controlled, single-blind trial was conducted involving two groups of female subjects affected by facial skin photoaging.
Summary · context
For two months, volunteers took a daily dose of MCN containing 200mg of hyaluronic acid, 500mg of L-carnosine, and 400mg of methylsulfonylmethane, or a placebo.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3111901011

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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