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Study · Animal study (in vivo) · mouse · 2019

7 results

The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma.

Jia Y, Lue Y, Swerdloff RS, Lasky JL, Panosyan EH, Dai-Ju J, Wang C

Experimental and molecular pathology11 May 2019Cited by 10 (Europe PMC)

PMID31085184 (opens in a new tab)PMCIDPMC6680022 (opens in a new tab)DOI10.1016/j.yexmp.2019.104261 (opens in a new tab)PepBankPUB-31085184
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG did not affect the significant anti-tumor action of TMZ.

    In plain wordsIn mice with human tumor grafts, HNG did not reduce the tumor-fighting effect of TMZ.

    Peptide
    Humanin
    Outcome
    No significant changeTMZ anti-tumor action with HNG
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    TMZ alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG did not affect TMZ's significant anti-tumor action.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG significantly prevented TMZ-induced male germ cell apoptosis.

    In plain wordsIn mice with human tumor grafts, HNG prevented the sperm-cell death that TMZ caused.

    Peptide
    Humanin
    Outcome
    DecreaseTMZ-induced male germ cell apoptosis
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    TMZ alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG significantly prevented TMZ-induced germ cell apoptosis and attenuated the suppressed total WBC and granulocyte counts in SCID mice with or without TMZ treatment.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG attenuated the suppressed total white blood cell count, with or without TMZ treatment.

    In plain wordsIn mice with human tumor grafts, HNG reduced the drop in white blood cell counts, with or without TMZ.

    Peptide
    Humanin
    Outcome
    IncreaseTotal white blood cell count
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    Vehicle or TMZ alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG significantly prevented TMZ-induced germ cell apoptosis and attenuated the suppressed total WBC and granulocyte counts in SCID mice with or without TMZ treatment.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG attenuated the suppressed granulocyte count, with or without TMZ treatment.

    In plain wordsIn mice with human tumor grafts, HNG reduced the drop in granulocyte counts, with or without TMZ.

    Peptide
    Humanin
    Outcome
    IncreaseGranulocyte count
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    Vehicle or TMZ alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG significantly prevented TMZ-induced germ cell apoptosis and attenuated the suppressed total WBC and granulocyte counts in SCID mice with or without TMZ treatment.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG attenuated TMZ-induced body weight loss.

    In plain wordsIn mice with human tumor grafts, HNG reduced the body weight loss that TMZ caused.

    Peptide
    Humanin
    Outcome
    IncreaseTMZ-induced body weight loss
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    TMZ alone
    Outcome group
    Body weight · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also attenuated TMZ-induced body weight loss and decrease of spleen and liver weights.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG attenuated the TMZ-induced decrease in spleen weight.

    In plain wordsIn mice with human tumor grafts, HNG reduced the spleen weight loss that TMZ caused.

    Peptide
    Humanin
    Outcome
    IncreaseTMZ-induced decrease in spleen weight
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    TMZ alone
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also attenuated TMZ-induced body weight loss and decrease of spleen and liver weights.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In SCID mice with human medulloblastoma xenografts, HNG attenuated the TMZ-induced decrease in liver weight.

    In plain wordsIn mice with human tumor grafts, HNG reduced the liver weight loss that TMZ caused.

    Peptide
    Humanin
    Outcome
    IncreaseTMZ-induced decrease in liver weight
    Study

    mousen: not reported in source

    Male SCID mice bearing human medulloblastoma DAOY xenografts
    Comparator
    TMZ alone
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also attenuated TMZ-induced body weight loss and decrease of spleen and liver weights.
    2 context sentences
    Summary · context
    In this study, we utilized severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma to study the effect of HNG in Temozolomide (TMZ) induced male germ cell apoptosis and white blood cell (WBC) suppression.
    Summary · context
    Three weeks later, groups of tumor-bearing mice received one of the following treatments: vehicle, HNG, TMZ, or TMZ + HNG.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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