In children with ventricular septal defect, the ROC area under the curve of plasma Tβ4, together with ALDOB, was higher than that of other candidate proteins.
In plain wordsIn children with a heart defect, the body's own thymosin beta‑4 in blood may help identify the defect.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Direction not reportedPlasma Tβ4 as biomarker for ventricular septal defect (ROC AUC)
- Study
n: not reported in source
- Outcome group
- Cardiovascular events · Cardiovascular
Source sentences
The areas under the receiver operating characteristic curve values of fructose-bisphosphate aldolase B (ALDOB) and thymosin beta-4 (Tβ4) were higher than those of other candidate proteins.
3 context sentences(design, population, supporting numbers)
ALDOB and Tβ4 might be potential biomarkers applied for identifying VSD in the further works.
Eight subjects with ventricular septal defect (VSD, a kind of congenital heart disease) and 11 health children were enrolled in tandem mass tags label-based quantitative proteomic analysis to compare plasma proteins differentially abundance.
The amount of ten proteins changed significantly (p < 0.05) in newly recruited 30 VSD compared with 15 control children, which were validated by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.