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Study · Animal study (in vivo) · pig · 2019

5 results

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria.

Zhang LH, Zhu XY, Eirin A, Nargesi AA, Woollard JR, Santelli A, Sun IO, Textor SC, Lerman LO

American journal of physiology. Renal physiology1 May 2019Cited by 32 (Europe PMC)

PMID31042059 (opens in a new tab)PMCIDPMC6692726 (opens in a new tab)DOI10.1152/ajprenal.00399.2018 (opens in a new tab)PepBankPUB-31042059
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with metabolic syndrome, elamipretide treatment decreased the elevated glomerular size.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced enlarged kidney filter units.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGlomerular size
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated metabolic syndrome pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg/day · subcutaneous · last month of dietAs given in this study (pig).

    Source sentences

    Summary
    Glomerular size and glomerular injury score were also elevated in MetS and decreased after ELAM treatment.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for the last month of diet, and lean controls (n = 6 pigs/group).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with metabolic syndrome, elamipretide treatment decreased the elevated glomerular injury score.

    In plain wordsIn pigs with metabolic syndrome, elamipretide lowered the kidney filter injury score.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGlomerular injury score
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated metabolic syndrome pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg/day · subcutaneous · last month of dietAs given in this study (pig).

    Source sentences

    Summary
    Glomerular size and glomerular injury score were also elevated in MetS and decreased after ELAM treatment.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for the last month of diet, and lean controls (n = 6 pigs/group).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with metabolic syndrome, elamipretide restored the increased podocyte injury.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reversed injury to kidney filter cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePodocyte injury
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated metabolic syndrome pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg/day · subcutaneous · last month of dietAs given in this study (pig).

    Source sentences

    Summary
    Evidence of podocyte injury, impaired podocyte mitochondria, and foot process width were all increased in MetS but restored with ELAM.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for the last month of diet, and lean controls (n = 6 pigs/group).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with metabolic syndrome, elamipretide restored impaired podocyte mitochondria.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reversed damage to mitochondria in kidney filter cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePodocyte mitochondrial impairment
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated metabolic syndrome pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg/day · subcutaneous · last month of dietAs given in this study (pig).

    Source sentences

    Summary
    Evidence of podocyte injury, impaired podocyte mitochondria, and foot process width were all increased in MetS but restored with ELAM.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for the last month of diet, and lean controls (n = 6 pigs/group).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with metabolic syndrome, elamipretide restored the increased foot process width.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reversed the widening of kidney filter cell extensions.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePodocyte foot process width
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated metabolic syndrome pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg/day · subcutaneous · last month of dietAs given in this study (pig).

    Source sentences

    Summary
    Evidence of podocyte injury, impaired podocyte mitochondria, and foot process width were all increased in MetS but restored with ELAM.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg·kg-1·day-1 sc) for the last month of diet, and lean controls (n = 6 pigs/group).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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