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Study · Animal study (in vivo) · mouse · 2019

6 results

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z

Redox biology10 Apr 2019Cited by 262 (Europe PMC)

PMID31015147 (opens in a new tab)PMCIDPMC6477631 (opens in a new tab)DOI10.1016/j.redox.2019.101192 (opens in a new tab)PepBankPUB-31015147
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN rescued neurovascular coupling responses.

    In plain wordsIn aged mice, NMN restored blood flow responses to brain activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNeurovascular coupling
    Study

    mousen: not reported in source

    Aged C57BL/6 mice
    Outcome group
    Cerebral blood flow · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation rescued NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory and gait coordination.
    1 context sentence
    Summary · context
    To test this hypothesis 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In aged mice, NMN increased endothelial NO-mediated vasodilation.

    In plain wordsIn aged mice, NMN increased nitric oxide-mediated widening of brain blood vessels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseEndothelial NO-mediated vasodilation
    Study

    mousen: not reported in source

    Aged C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation rescued NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory and gait coordination.
    1 context sentence
    Summary · context
    To test this hypothesis 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN-associated recovery of neurovascular coupling accompanied improved spatial working memory.

    In plain wordsIn aged mice, NMN treatment was associated with better spatial working memory.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSpatial working memory
    Study

    mousen: not reported in source

    Aged C57BL/6 mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation rescued NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory and gait coordination.
    1 context sentence
    Summary · context
    To test this hypothesis 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN-associated recovery of neurovascular coupling accompanied improved gait coordination.

    In plain wordsIn aged mice, NMN treatment was associated with better walking coordination.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseGait coordination
    Study

    mousen: not reported in source

    Aged C57BL/6 mice
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    NMN supplementation rescued NVC responses by increasing endothelial NO-mediated vasodilation, which was associated with significantly improved spatial working memory and gait coordination.
    1 context sentence
    Summary · context
    To test this hypothesis 24-month-old C57BL/6 mice were treated with nicotinamide mononucleotide (NMN), a key NAD+ intermediate, for 2 weeks.
  5. 05LabIn vitro (cells)Mechanism

    In cultured endothelial cells from aged animals, NMN protected against mitochondrial reactive oxygen species production through sirtuin-dependent effects.

    In plain wordsIn cells from aged animals, NMN reduced mitochondrial reactive oxygen species through effects dependent on sirtuins.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMitochondrial reactive oxygen species
    Study

    n: not reported in source

    Cultured cerebromicrovascular endothelial cells from aged animals
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These findings are paralleled by the sirtuin-dependent protective effects of NMN on mitochondrial production of reactive oxygen species and mitochondrial bioenergetics in cultured cerebromicrovascular endothelial cells derived from aged animals.
  6. 06LabIn vitro (cells)Mechanism

    In cultured endothelial cells from aged animals, NMN protected mitochondrial bioenergetics through sirtuin-dependent effects.

    In plain wordsIn cells from aged animals, NMN protected mitochondrial energy function through effects dependent on sirtuins.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial bioenergetics
    Study

    n: not reported in source

    Cultured cerebromicrovascular endothelial cells from aged animals
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These findings are paralleled by the sirtuin-dependent protective effects of NMN on mitochondrial production of reactive oxygen species and mitochondrial bioenergetics in cultured cerebromicrovascular endothelial cells derived from aged animals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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