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Study · Not a test of the peptide alone · 2019

5 results

The kisspeptin derivative kissorphin reduces the acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in rats.

Gibula-Tarlowska E, Grochecki P, Silberring J, Kotlinska JH

Alcohol (Fayetteville, N.Y.)11 Apr 2019Cited by 9 (Europe PMC)

PMID30981809 (opens in a new tab)DOI10.1016/j.alcohol.2019.04.001 (opens in a new tab)PepBankPUB-30981809
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In rats, intravenous kissorphin (a kisspeptin‑10 derivative) given before each ethanol dose dose-dependently inhibited acquisition of ethanol-induced conditioned place preference.

    In plain wordsIn rats, kissorphin, a peptide derived from kisspeptin‑10, reduced the learning of a preference for the place linked to ethanol.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAcquisition of ethanol-induced conditioned place preference
    Study

    ratn: not reported in source

    Ethanol-induced conditioned place preference
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    Our experiments showed that KSO, given intravenously (i.v.) at the doses of 1, 3, and 10 nmol before every ethanol administration, inhibited the acquisition
    1 context sentence
    Summary · context
    The ethanol-CPP was established (conditioning for 5 days) by intraperitoneal (i.p.) administration of ethanol (1 g/kg, 20%, w/v) using an unbiased procedure.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In rats, kissorphin given acutely before the post-conditioning test dose-dependently inhibited expression of ethanol-induced conditioned place preference.

    In plain wordsIn rats, kissorphin lowered the preference for the ethanol-linked place when given before the test.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseExpression of ethanol-induced conditioned place preference
    Study

    ratn: not reported in source

    Ethanol-induced conditioned place preference
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    Our experiments showed that KSO, given intravenously (i.v.) at the doses of 1, 3, and 10 nmol before every ethanol administration, inhibited the acquisition and, given acutely before the post-conditioning test or before the priming dose of ethanol, inhibited the expression and reinstatement of ethan…
    1 context sentence
    Summary · context
    The ethanol-CPP was established (conditioning for 5 days) by intraperitoneal (i.p.) administration of ethanol (1 g/kg, 20%, w/v) using an unbiased procedure.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  3. 03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In rats, kissorphin given before the ethanol priming dose dose-dependently inhibited reinstatement of ethanol-induced conditioned place preference.

    In plain wordsIn rats, kissorphin lowered the return of the ethanol-linked place preference after a priming dose.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseReinstatement of ethanol-induced conditioned place preference
    Study

    ratn: not reported in source

    Ethanol-induced conditioned place preference
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    Our experiments showed that KSO, given intravenously (i.v.) at the doses of 1, 3, and 10 nmol before every ethanol administration, inhibited the acquisition and, given acutely before the post-conditioning test or before the priming dose of ethanol, inhibited the expression and reinstatement of ethan…
    1 context sentence
    Summary · context
    The ethanol-CPP was established (conditioning for 5 days) by intraperitoneal (i.p.) administration of ethanol (1 g/kg, 20%, w/v) using an unbiased procedure.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  4. 04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome

    In rats, kissorphin given by itself induced neither place preference nor aversion.

    In plain wordsIn rats, kissorphin alone did not cause a preference for or aversion to a place.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlace preference or aversion from kissorphin alone
    Study

    ratn: not reported in source

    Ethanol-induced conditioned place preference
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    KSO given by itself neither induced place preference nor aversion
    1 context sentence
    Summary · context
    The ethanol-CPP was established (conditioning for 5 days) by intraperitoneal (i.p.) administration of ethanol (1 g/kg, 20%, w/v) using an unbiased procedure.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  5. 05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Safety outcome

    In rats, kissorphin given by itself did not alter locomotor activity or coordination.

    In plain wordsIn rats, kissorphin alone did not change movement or coordination.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLocomotor activity and coordination
    Study

    ratn: not reported in source

    Ethanol-induced conditioned place preference
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood

    Source sentences

    Summary
    did not alter locomotor activity and coordination of rats.
    1 context sentence
    Summary · context
    The ethanol-CPP was established (conditioning for 5 days) by intraperitoneal (i.p.) administration of ethanol (1 g/kg, 20%, w/v) using an unbiased procedure.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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