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Study · Measured the body's own peptide · 2019

9 results

Humanin levels in human seminal plasma and spermatozoa are related to sperm quality.

Rao M, Wu Z, Wen Y, Wang R, Zhao S, Tang L

Andrology28 Mar 2019Cited by 27 (Europe PMC)

PMID30920769 (opens in a new tab)DOI10.1111/andr.12614 (opens in a new tab)PepBankPUB-30920769
Source linkPubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In men attending an andrology clinic, seminal plasma humanin ranged from 24.4 to 285.1 pg/mL, with a median of 89.7 pg/mL.

    In plain wordsIn men tested at a fertility clinic, natural humanin was present in semen fluid at a median of 89.7 pg/mL.

    Peptide
    Humanin
    Outcome
    Not applicableSeminal plasma humanin concentration
    Study

    n = 164

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Seminal plasma humanin median
    89.7 pg/mL
    All patients
    Seminal plasma humanin range
    24.4 to 285.1 pg/mL
    All patients

    Source sentences

    Summary
    Humanin concentrations in the SP ranged from 24.4 to 285.1 pg/mL, with a median of 89.7 pg/mL.
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Seminal plasma humanin correlated positively with sperm concentration.

    In plain wordsHigher natural humanin levels in semen fluid were linked to higher sperm concentration.

    Peptide
    Humanin
    Outcome
    Not applicableSeminal plasma humanin correlation with sperm concentration
    Study

    n = 164

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Spearman r
    0.75 r
    SP humanin vs sperm concentration

    Source sentences

    Summary
    Spearman analysis showed a positive and significant correlation between SP humanin concentration and sperm concentration (r = 0.75, p < 0.001)
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Seminal plasma humanin correlated positively with progressive sperm motility.

    In plain wordsHigher natural humanin levels in semen fluid were linked to better sperm movement.

    Peptide
    Humanin
    Outcome
    Not applicableSeminal plasma humanin correlation with progressive sperm motility
    Study

    n = 164

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Spearman r
    0.29 r
    SP humanin vs progressive motility

    Source sentences

    Summary
    and progressive sperm motility (r = 0.29, p < 0.001).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Humanin level in spermatozoa was positively associated with progressive sperm motility.

    In plain wordsHigher natural humanin levels inside sperm were linked to better sperm movement.

    Peptide
    Humanin
    Outcome
    Not applicableSperm humanin correlation with progressive sperm motility
    Study

    n = 164

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Spearman r
    0.7 r
    Sperm humanin vs progressive motility

    Source sentences

    Summary
    Sperm humanin level was significantly and positively associated with progressive sperm motility (r = 0.70, p < 0.001).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyMechanism

    In men attending an andrology clinic, the body's own humanin was expressed in the midpiece of spermatozoa.

    In plain wordsIn men tested at a fertility clinic, natural humanin was found in the midpiece of sperm.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin localization in spermatozoa
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Humanin was expressed in the midpiece of the spermatozoa.
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    Seminal plasma humanin was higher in patients with normospermia than in patients with oligospermia.

    In plain wordsNatural humanin levels in semen fluid were higher in men with normal sperm counts than in men with low sperm counts.

    Peptide
    Humanin
    Outcome
    IncreaseSeminal plasma humanin, normospermia versus oligospermia
    Study

    n: not reported in source

    Comparator
    Patients with oligospermia
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The SP humanin concentrations in patients with normospermia were significantly higher than those in patients with oligospermia (p < 0.001), asthenospermia (p = 0.002), and oligoasthenospermia (p < 0.001).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    Seminal plasma humanin was higher in patients with normospermia than in patients with asthenospermia.

    In plain wordsNatural humanin levels in semen fluid were higher in men with normal sperm than in men with poorly moving sperm.

    Peptide
    Humanin
    Outcome
    IncreaseSeminal plasma humanin, normospermia versus asthenospermia
    Study

    n: not reported in source

    Comparator
    Patients with asthenospermia
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The SP humanin concentrations in patients with normospermia were significantly higher than those in patients with oligospermia (p < 0.001), asthenospermia (p = 0.002), and oligoasthenospermia (p < 0.001).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    Seminal plasma humanin was higher in patients with normospermia than in patients with oligoasthenospermia.

    In plain wordsNatural humanin levels in semen fluid were higher in men with normal sperm than in men with low counts and poor movement.

    Peptide
    Humanin
    Outcome
    IncreaseSeminal plasma humanin, normospermia versus oligoasthenospermia
    Study

    n: not reported in source

    Comparator
    Patients with oligoasthenospermia
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The SP humanin concentrations in patients with normospermia were significantly higher than those in patients with oligospermia (p < 0.001), asthenospermia (p = 0.002), and oligoasthenospermia (p < 0.001).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  9. 09HumanEndogenous levelObservational studyOther

    Humanin level was higher in swim-up spermatozoa than in non-swim-up spermatozoa.

    In plain wordsNatural humanin levels were higher in the sperm that swam up than in sperm that did not.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin in swim-up versus non-swim-up spermatozoa
    Study

    n: not reported in source

    Comparator
    Non-swim-up spermatozoa
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In addition, a significantly higher level of humanin was found in swim-up spermatozoa than in non-swim-up spermatozoa (p = 0.03).
    1 context sentence
    Summary · context
    Semen samples for SP/sperm humanin level measurement were collected from 164 patients who attended our andrology clinic for fertility evaluation.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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