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Study · In vitro (cells) · 2019

12 results

Carnosine Suppresses Human Colorectal Cell Migration and Intravasation by Regulating EMT and MMP Expression.

Hsieh SL, Hsieh S, Lai PY, Wang JJ, Li CC, Wu CC

The American journal of Chinese medicine1 Jan 2019Cited by 18 (Europe PMC)

PMID30909731 (opens in a new tab)DOI10.1142/s0192415x19500241 (opens in a new tab)PepBankPUB-30909731
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine inhibited migration.

    In plain wordsIn cells, carnosine inhibited migration.

    Peptide
    L-carnosine
    Outcome
    DecreaseMigration
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that both migration and invasion were inhibited in cells treated with carnosine.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  2. 02LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine inhibited invasion.

    In plain wordsIn cells, carnosine inhibited invasion.

    Peptide
    L-carnosine
    Outcome
    DecreaseInvasion
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results showed that both migration and invasion were inhibited in cells treated with carnosine.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  3. 03LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine significantly decreased Twist-1 protein levels.

    In plain wordsIn cells, carnosine significantly decreased Twist-1 protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseTwist-1 protein
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found significant decreases in Twist-1 protein levels and increases in E-cadherin protein levels in HCT-116 cells after carnosine exposure.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  4. 04LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine significantly increased E-cadherin protein levels.

    In plain wordsIn cells, carnosine significantly increased E-cadherin protein levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseE-cadherin protein
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found significant decreases in Twist-1 protein levels and increases in E-cadherin protein levels in HCT-116 cells after carnosine exposure.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  5. 05LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine decreased uPA mRNA levels.

    In plain wordsIn cells, carnosine decreased uPA mRNA levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseuPA mRNA
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  6. 06LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine decreased uPA protein levels.

    In plain wordsIn cells, carnosine decreased uPA protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseuPA protein
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  7. 07LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine decreased MMP-9 mRNA levels.

    In plain wordsIn cells, carnosine decreased MMP-9 mRNA levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseMMP-9 mRNA
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  8. 08LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine decreased MMP-9 protein levels.

    In plain wordsIn cells, carnosine decreased MMP-9 protein levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseMMP-9 protein
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  9. 09LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine increased TIMP-1 mRNA levels.

    In plain wordsIn cells, carnosine increased TIMP-1 mRNA levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseTIMP-1 mRNA
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  10. 10LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine increased TIMP-1 protein levels.

    In plain wordsIn cells, carnosine increased TIMP-1 protein levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseTIMP-1 protein
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Although plasminogen activator (uPA) and MMP-9 mRNA and protein levels were decreased, TIMP-1 mRNA and protein levels were increased.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  11. 11LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine reduced cytosolic phosphorylated I κ B levels.

    In plain wordsIn cells, carnosine reduced cytosolic phosphorylated I κ B levels.

    Peptide
    L-carnosine
    Outcome
    DecreaseCytosolic phosphorylated I κ B
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, the cytosolic levels of phosphorylated I κ B (p-I κ B) and NF- κ B DNA-binding activity were reduced after carnosine treatment.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.
  12. 12LabIn vitro (cells)Mechanism

    In HCT-116 cells, carnosine reduced NF-κB DNA-binding activity.

    In plain wordsIn cells, carnosine reduced NF-κB DNA-binding activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseNF-κB DNA-binding activity
    Study

    humann: not reported in source

    HCT-116 cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, the cytosolic levels of phosphorylated I κ B (p-I κ B) and NF- κ B DNA-binding activity were reduced after carnosine treatment.
    1 context sentence
    Summary · context
    To investigate the mechanism by which carnosine regulates the migration and intravasation of human colorectal cancer (CRC) cells, we used cultured HCT-116 cells as an experimental model in this study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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