Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis.

Kim SR, Eirin A, Zhang X, Lerman A, Lerman LO

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology1 Jan 2019Cited by 34 (Europe PMC)

PMID30907989PMCIDPMC6519989DOI10.33594/000000044PepBankPUB-30907989

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide normalized renal blood flow in the stenotic kidney.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide restored blood flow in the affected kidney.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseStenotic kidney renal blood flow
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
Elamipretide normalized STK-RBF and GFR
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798901
02AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide normalized glomerular filtration rate in the stenotic kidney.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide restored kidney filtration in the affected kidney.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseStenotic kidney glomerular filtration rate
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
Elamipretide normalized STK-RBF and GFR
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798902
03AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide alleviated renal fibrosis.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide reduced kidney scarring.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRenal fibrosis
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
Elamipretide normalized STK-RBF and GFR, alleviated fibrosis and oxidative stress
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798903
04AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide alleviated renal oxidative stress.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide reduced oxidative stress in the kidney.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRenal oxidative stress
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
Elamipretide normalized STK-RBF and GFR, alleviated fibrosis and oxidative stress
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798904
05AnimalAnimal study (in vivo)Mechanism
In pigs with renal artery stenosis, elamipretide restored mitochondrial cardiolipin in the kidney.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide restored a key mitochondrial fat in the kidney.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial cardiolipin
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
restored mitochondrial cardiolipin, biogenesis, and mitophagy in ARAS
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798905
06AnimalAnimal study (in vivo)Mechanism
In pigs with renal artery stenosis, elamipretide restored mitochondrial biogenesis in the kidney, which ARAS had upregulated.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide restored the making of new mitochondria in the kidney.
Peptide
Elamipretide (SS-31)
Outcome
MixedMitochondrial biogenesis
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
restored mitochondrial cardiolipin, biogenesis, and mitophagy in ARAS
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798906
07AnimalAnimal study (in vivo)Mechanism
In pigs with renal artery stenosis, elamipretide restored mitophagy in the kidney.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide restored the clearing of damaged mitochondria in the kidney.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitophagy
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Mitochondrial function · Kidney and urinary
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
restored mitochondrial cardiolipin, biogenesis, and mitophagy in ARAS
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798907
08AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide did not change senescence-associated secretory phenotype markers.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide did not change markers of the secretions of aging cells.
Peptide
Elamipretide (SS-31)
Outcome
No significant changeSASP markers
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
but did not change SASP markers, and attenuated only senescenceassociated β-galactosidase activity and p53 gene expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798908
09AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide attenuated senescence-associated beta-galactosidase activity.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide reduced one marker of cell aging.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseSenescence-associated beta-galactosidase activity
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
attenuated only senescenceassociated β-galactosidase activity and p53 gene expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798909
10AnimalAnimal study (in vivo)Efficacy outcome
In pigs with renal artery stenosis, elamipretide attenuated p53 gene expression.
In plain wordsIn pigs with narrowed kidney arteries, elamipretide reduced p53 gene expression, a marker of cell aging.
Peptide
Elamipretide (SS-31)
Outcome
Decreasep53 gene expression
Study
pign = 6
Unilateral atherosclerotic renal artery stenosis (ARAS)
Comparator
Untreated ARAS
Outcome group
Aging markers · Aging and longevity
Studied dose
Dose not stated · subcutaneous · 4 weeksAs given in this study (pig).
Source sentences
Summary
attenuated only senescenceassociated β-galactosidase activity and p53 gene expression.
1 context sentence(design, population, supporting numbers)
Summary · context
Domestic pigs were randomized to control and unilateral ARAS untreated or treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS or sham (n=6 each).
Report a problemFND-3090798910

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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Mitochondrial Protection Partly Mitigates Kidney Cellular Senescence in Swine Atherosclerotic Renal Artery Stenosis.

Summary

Results from this study10

Version history

Subjects

Publication types

MeSH terms

Keywords