Association between thymosin beta4 and non-alcoholic fatty liver disease.

Jiang Y, Zhang Y, Ma CH, Zhang ZG, Li M, Ji YL, Qi FX

Revista espanola de enfermedades digestivas1 Apr 2019Cited by 5 (Europe PMC)

PMID30896961DOI10.17235/reed.2019.5927/2018PepBankPUB-30896961

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults with non-alcoholic fatty liver disease, serum Tβ4 was lower than in healthy controls.
In plain wordsIn adults with fatty liver disease, the body's own thymosin beta‑4 level in blood was lower than in healthy people.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum Tβ4 level in NAFLD versus healthy controls
Study
n = 206
Comparator
Healthy controls
Outcome group
Liver fat and liver function · Liver
Measurements
Serum Tβ4
3.2 mg/l
NAFLD patients
Serum Tβ4
5.53 mg/l
healthy controls
Source sentences
Summary
serum Tβ4 content was 3.20 ± 0.98 mg/l in NAFLD patients (n = 76) and 5.53 ± 1.24 mg/l in healthy controls (n = 130); the difference between the two groups was statistically significant (p = 0.000).
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696101
02HumanEndogenous levelObservational studyOther
In multivariate logistic regression, higher serum Tβ4 was an independent predictor associated with lower odds of NAFLD diagnosis.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower odds of having fatty liver disease.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTβ4 as independent predictor of NAFLD diagnosis
Study
n = 206
Outcome group
Liver fat and liver function · Liver
Measurements
Odds ratio
0.343
Tβ4
95% CI
0.24 to 0.491
Tβ4
Source sentences
Summary
Multivariate logistic regression analysis identified Tβ4 (OR = 0.343, 95% CI 0.240-0.491, p < 0.001), LDL (OR = 1.019, 95% CI 1.007-1.030, p = 0.001), ALT (OR = 1.021, 95% CI 1.001-1.041, p = 0.040) and IL-6 (OR = 1.443, 95% CI 1.079-1.929, p = 0.013) as independent predictors of NAFLD diagnosis.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696102
03HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated negatively with total cholesterol.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower total cholesterol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with total cholesterol
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.163
total cholesterol
Source sentences
Summary
Serum Tβ4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696103
04HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated negatively with triglycerides.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower triglycerides.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with triglycerides
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.253
TG
Source sentences
Summary
Serum Tβ4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696104
05HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated negatively with AST.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower AST, a liver enzyme.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with AST
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.143
AST
Source sentences
Summary
Serum Tβ4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696105
06HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated negatively with GGT.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower GGT, a liver enzyme.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with GGT
Study
n: not reported in source
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.245
GGT
Source sentences
Summary
Serum Tβ4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696106
07HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated negatively with IL-6.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to lower IL-6, an inflammation marker.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with IL-6
Study
n: not reported in source
Outcome group
Inflammation markers · Liver
Measurements
Correlation coefficient
−0.155
IL-6
Source sentences
Summary
Serum Tβ4 levels had a significant negative correlation with total cholesterol, TG, AST, GGT and IL-6 (p < 0.05 for all) and the correlation coefficient values were -0.163, -0.253, -0.143, -0.245 and -0.155, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696107
08HumanEndogenous levelObservational studyOther
Serum Tβ4 levels correlated positively with serum adiponectin.
In plain wordsHigher natural thymosin beta‑4 levels in blood were linked to higher adiponectin.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCorrelation of serum Tβ4 with adiponectin
Study
n: not reported in source
Outcome group
Inflammation markers · Liver
Measurements
Correlation coefficient
0.143
adiponectin
Source sentences
Summary
Serum Tβ4 levels were positively correlated with serum adiponectin levels, with a correlation coefficient value of 0.143.
2 context sentences(design, population, supporting numbers)
Summary · context
a total of 76 NAFLD patients and 130 healthy controls were included in the study.
Summary · context
Serum levels of Tβ4, IL-6 and adiponectin were determined by ELISA.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3089696108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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