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Study · Animal study (in vivo) · mouse · 2020

3 results

The neuroprotective properties of carnosine in a mouse model of manganism is mediated via mitochondria regulating and antioxidative mechanisms.

Ommati MM, Ommati MM, Heidari R, Ghanbarinejad V, Aminian A, Abdoli N, Niknahad H

Nutritional neuroscience11 Mar 2019Cited by 39 (Europe PMC)

PMID30856059 (opens in a new tab)DOI10.1080/1028415x.2018.1552399 (opens in a new tab)PepBankPUB-30856059
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Mn-exposed mice, carnosine alleviated locomotor deficits compared with Mn alone.

    In plain wordsIn mice exposed to manganese, carnosine reduced movement problems compared with manganese alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseLocomotor deficit
    Study

    mousen: not reported in source

    Mn-induced neurotoxicity in male C57BL/6 mice
    Comparator
    Mn alone
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10, 50, and 100 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    It was found that carnosine supplementation (10, 50, and 100 mg/kg, i.p) alleviated the Mn-induced locomotor deficit.
    1 context sentence
    Summary · context
    Male C57BL/6 mice received Mn (100 mg/kg, s.c) alone and/or in combination with carnosine (10, 50, and 100 mg/kg, i.p).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Mn-exposed mice, carnosine mitigated brain oxidative stress biomarkers compared with Mn alone.

    In plain wordsIn mice exposed to manganese, carnosine reduced brain oxidative stress markers compared with manganese alone.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain oxidative stress biomarkers
    Study

    mousen: not reported in source

    Mn-induced neurotoxicity in male C57BL/6 mice
    Comparator
    Mn alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    10, 50, and 100 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, this peptide mitigated oxidative stress biomarkers and preserved brain tissue mitochondrial functionality in the animal model of manganism.
    1 context sentence
    Summary · context
    Male C57BL/6 mice received Mn (100 mg/kg, s.c) alone and/or in combination with carnosine (10, 50, and 100 mg/kg, i.p).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Mn-exposed mice, carnosine preserved brain mitochondrial functionality compared with Mn alone.

    In plain wordsIn mice exposed to manganese, carnosine preserved brain mitochondrial function compared with manganese alone.

    Peptide
    L-carnosine
    Outcome
    IncreaseBrain mitochondrial functionality
    Study

    mousen: not reported in source

    Mn-induced neurotoxicity in male C57BL/6 mice
    Comparator
    Mn alone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    10, 50, and 100 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, this peptide mitigated oxidative stress biomarkers and preserved brain tissue mitochondrial functionality in the animal model of manganism.
    1 context sentence
    Summary · context
    Male C57BL/6 mice received Mn (100 mg/kg, s.c) alone and/or in combination with carnosine (10, 50, and 100 mg/kg, i.p).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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