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Study · Randomized controlled trial · n = 92 · 2019

7 results

Effects of Liraglutide Combined with Insulin on Oxidative Stress and Serum MCP-1 and NF-kB Levels in Type 2 Diabetes.

Liu X, Huang J, Li J, Mao Q, He J

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP1 Mar 2019Cited by 23 (Europe PMC)

PMID30823945 (opens in a new tab)DOI10.29271/jcpsp.2019.03.218 (opens in a new tab)PepBankPUB-30823945
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with type 2 diabetes, fasting blood glucose after treatment was lower with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, fasting blood sugar was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseFasting blood glucose after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treatment, levels of the fasting blood glucose, 2h postprandial blood glucose, serum MDA, serum MCP-1, and serum NF-kB in the observation group were lower than those in the control group (all p<0.001).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with type 2 diabetes, 2-hour postprandial blood glucose after treatment was lower with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, blood sugar after meals was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    Decrease2-hour postprandial blood glucose after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treatment, levels of the fasting blood glucose, 2h postprandial blood glucose, serum MDA, serum MCP-1, and serum NF-kB in the observation group were lower than those in the control group (all p<0.001).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  3. 03HumanRandomized controlled trialMechanism

    In patients with type 2 diabetes, serum MDA, a marker of oxidative stress, was lower with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, a blood marker of oxidative damage was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseSerum malondialdehyde (MDA) after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Oxidative stress · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treatment, levels of the fasting blood glucose, 2h postprandial blood glucose, serum MDA, serum MCP-1, and serum NF-kB in the observation group were lower than those in the control group (all p<0.001).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  4. 04HumanRandomized controlled trialMechanism

    In patients with type 2 diabetes, serum MCP-1 was lower with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, an inflammation marker (MCP-1) was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseSerum MCP-1 after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treatment, levels of the fasting blood glucose, 2h postprandial blood glucose, serum MDA, serum MCP-1, and serum NF-kB in the observation group were lower than those in the control group (all p<0.001).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  5. 05HumanRandomized controlled trialMechanism

    In patients with type 2 diabetes, serum NF-kB was lower with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, an inflammation marker (NF-kB) was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseSerum NF-kB after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After treatment, levels of the fasting blood glucose, 2h postprandial blood glucose, serum MDA, serum MCP-1, and serum NF-kB in the observation group were lower than those in the control group (all p<0.001).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  6. 06HumanRandomized controlled trialMechanism

    In patients with type 2 diabetes, serum SOD, an antioxidant enzyme, was higher with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, a protective antioxidant enzyme (SOD) was higher with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    IncreaseSerum superoxide dismutase (SOD) after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Oxidative stress · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The serum SOD level and blood glucose target rate were higher in the observation group than those in the control group (p<0.001 and p=0.010, respectively).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In patients with type 2 diabetes, more patients reached the blood glucose target with liraglutide plus insulin than with insulin alone.

    In plain wordsIn people with type 2 diabetes, more reached their blood sugar target with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    IncreaseBlood glucose target rate after treatment
    Study

    n = 92

    Comparator
    Insulin alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The serum SOD level and blood glucose target rate were higher in the observation group than those in the control group (p<0.001 and p=0.010, respectively).
    2 context sentences
    Summary · context
    Ninety-two patients with type 2 diabetes were selected as objects of study.
    Summary · context
    The control group was treated with insulin alone, and the observation group was treated with liraglutide in combination with insulin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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