Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model.

Wu X, Pang Y, Zhang Z, Li X, Wang C, Lei Y, Li A, Yu L, Ye J

Acta biochimica et biophysica Sinica1 Apr 2019Cited by 34 (Europe PMC)

PMID30811524DOI10.1093/abbs/gmz020PepBankPUB-30811524

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, SS‑31 ameliorated the reduction in electroretinography a-wave amplitude.
In plain wordsIn rats with glaucoma, SS‑31 lessened the drop in the retina's electrical response (a-wave).
Peptide
Elamipretide (SS-31)
Outcome
IncreaseERG a-wave amplitude
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, SS‑31 ameliorated the reduction in electroretinography b-wave amplitude.
In plain wordsIn rats with glaucoma, SS‑31 lessened the drop in the retina's electrical response (b-wave).
Peptide
Elamipretide (SS-31)
Outcome
IncreaseERG b-wave amplitude
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, SS‑31 ameliorated the reduction in flash visual-evoked potential amplitude.
In plain wordsIn rats with glaucoma, SS‑31 lessened the drop in the brain's response to light flashes.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseFlash visual-evoked potential amplitude
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS-31 ameliorated the reductions in the a- and b-wave amplitudes on ERG and the F-VEP amplitude in glaucomatous eyes.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, ganglion cell complex thickness was preserved in the SS‑31 group compared with the non-treated glaucoma group.
In plain wordsIn rats with glaucoma, SS‑31 preserved the thickness of the inner retina compared with untreated glaucoma rats.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseGanglion cell complex thickness
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Comparator
Non-treated glaucoma group
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were increased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152404
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, TUNEL-positive cells in the retina were decreased in the SS‑31 group compared with the non-treated glaucoma group.
In plain wordsIn rats with glaucoma, SS‑31 reduced the number of dying retinal cells compared with untreated glaucoma rats.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseTUNEL-positive apoptotic retinal cells
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Comparator
Non-treated glaucoma group
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were increased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152405
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental glaucoma, Brn3a-positive retinal ganglion cells were increased in the SS‑31 group compared with the non-treated glaucoma group.
In plain wordsIn rats with glaucoma, SS‑31 kept more retinal nerve cells alive compared with untreated glaucoma rats.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseBrn3a-positive retinal ganglion cells
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Comparator
Non-treated glaucoma group
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
GCC thickness was preserved, TUNEL-positive cells were decreased in the retina, and Brn3a-positive RGCs were increased in the SS-31-treated glaucoma group compared with those in the non-treated glaucoma group.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152406
07AnimalAnimal study (in vivo)Mechanism
In rats with experimental glaucoma, SS‑31 significantly reduced retinal MDA levels.
In plain wordsIn rats with glaucoma, SS‑31 lowered a marker of oxidative damage in the retina.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRetinal MDA level
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS-31 significantly reduced MDA levels and increased SOD2 levels after glaucoma induction.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152407
08AnimalAnimal study (in vivo)Mechanism
In rats with experimental glaucoma, SS‑31 increased retinal SOD2 levels.
In plain wordsIn rats with glaucoma, SS‑31 raised the level of a mitochondrial antioxidant enzyme in the retina.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseRetinal SOD2 level
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS-31 significantly reduced MDA levels and increased SOD2 levels after glaucoma induction.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152408
09AnimalAnimal study (in vivo)Mechanism
In rats with experimental glaucoma, SS‑31 administration significantly suppressed cytochrome c release.
In plain wordsIn rats with glaucoma, SS‑31 reduced release of cytochrome c, a signal that starts cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCytochrome c release
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152409
10AnimalAnimal study (in vivo)Mechanism
In rats with experimental glaucoma, SS‑31 administration upregulated the anti-apoptotic protein Bcl-2.
In plain wordsIn rats with glaucoma, SS‑31 raised a protein that protects cells from death.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseBcl-2 expression
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152410
11AnimalAnimal study (in vivo)Mechanism
In rats with experimental glaucoma, SS‑31 administration downregulated the pro-apoptotic protein Bax.
In plain wordsIn rats with glaucoma, SS‑31 lowered a protein that promotes cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseBax expression
Study
ratn: not reported in source
microsphere-induced experimental glaucoma
Outcome group
Neuroprotection · Eye
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Significant suppression of cyt c release, upregulation of Bcl-2, and downregulation of Bax were observed following SS-31 administration.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce ele…
Report a problemFND-3081152411

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model.

Summary

Results from this study11

Version history

Subjects

Publication types

MeSH terms

Keywords