Efficacy of mesotherapy with tranexamic acid and ascorbic acid with and without glutathione in treatment of melasma: A split face comparative trial.

Iraji F, Nasimi M, Asilian A, Faghihi G, Mozafarpoor S, Hafezi H

Journal of cosmetic dermatology8 Feb 2019Cited by 20 (Europe PMC)

PMID30735611DOI10.1111/jocd.12874PepBankPUB-30735611

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In melasma patients, adding glutathione to tranexamic acid and vitamin C produced significantly greater mMASI reduction than the cocktail without glutathione.
In plain wordsIn melasma patients, adding glutathione reduced pigmentation scores more than tranexamic acid and vitamin C alone.
Peptide
Glutathione
Outcome
DecreaseBetween-cocktail mMASI difference
Study
n = 30
Comparator
Tranexamic acid and vitamin C without glutathione (cocktail B)
Outcome group
Pigmentation · Skin and wound
Studied dose
2% · mesotherapy · six sessions at 2-week intervalsAs given in this study (human).
Measurements
Additional mMASI reduction
1.28 NA
cocktail A versus B
Reported ± uncertainty for additional mMASI reduction
0.64 NA
cocktail A versus B at 12 weeks; estimate 1.28; uncertainty type not stated
P value for between-cocktail mMASI reduction difference
< 0.001 NA
cocktail A versus B at 12 weeks
Source sentences
Summary
Comparison between two groups 12 weeks after treatment showed significantly more reduction (1.28 ± 0.64) of mMASI score with cocktail A than B (P-value < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics.
Summary · context
Then, patients underwent melasma therapy using Cocktail A (TA 4 mg/mL; vitamin C 3% and glutathione 2%) on their right half of the face and Cocktail B (TA 4 mg/mL and vitamin C 3%) on their left half of the face, with mesotherapy technique.
Report a problemFND-3073561102
02HumanRandomized controlled trialSafety outcome
In melasma patients, erythema did not differ significantly between cocktails with and without glutathione.
In plain wordsIn melasma patients, redness did not differ significantly between cocktails with and without glutathione.
Peptide
Glutathione
Outcome
No significant changeErythema
Study
n = 30
Comparator
Cocktail B without glutathione
Outcome group
Adverse events · Skin and wound
Studied dose
2% · mesotherapy · six sessions at 2-week intervalsAs given in this study (human).
Measurements
P value for between-cocktail erythema comparison
> 0.05 NA
cocktail A with glutathione versus cocktail B without glutathione
Source sentences
Summary
Erythema, edema, and ecchymosis was not significantly different among two cocktails (P-value > 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics.
Summary · context
Then, patients underwent melasma therapy using Cocktail A (TA 4 mg/mL; vitamin C 3% and glutathione 2%) on their right half of the face and Cocktail B (TA 4 mg/mL and vitamin C 3%) on their left half of the face, with mesotherapy technique.
Report a problemFND-3073561103
03HumanRandomized controlled trialSafety outcome
In melasma patients, edema did not differ significantly between cocktails with and without glutathione.
In plain wordsIn melasma patients, swelling did not differ significantly between cocktails with and without glutathione.
Peptide
Glutathione
Outcome
No significant changeEdema
Study
n = 30
Comparator
Cocktail B without glutathione
Outcome group
Adverse events · Skin and wound
Studied dose
2% · mesotherapy · six sessions at 2-week intervalsAs given in this study (human).
Measurements
P value for between-cocktail edema comparison
> 0.05 NA
cocktail A with glutathione versus cocktail B without glutathione
Source sentences
Summary
Erythema, edema, and ecchymosis was not significantly different among two cocktails (P-value > 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics.
Summary · context
Then, patients underwent melasma therapy using Cocktail A (TA 4 mg/mL; vitamin C 3% and glutathione 2%) on their right half of the face and Cocktail B (TA 4 mg/mL and vitamin C 3%) on their left half of the face, with mesotherapy technique.
Report a problemFND-3073561104
04HumanRandomized controlled trialSafety outcome
In melasma patients, ecchymosis did not differ significantly between cocktails with and without glutathione.
In plain wordsIn melasma patients, bruising did not differ significantly between cocktails with and without glutathione.
Peptide
Glutathione
Outcome
No significant changeEcchymosis
Study
n = 30
Comparator
Cocktail B without glutathione
Outcome group
Adverse events · Skin and wound
Studied dose
2% · mesotherapy · six sessions at 2-week intervalsAs given in this study (human).
Measurements
P value for between-cocktail ecchymosis comparison
> 0.05 NA
cocktail A with glutathione versus cocktail B without glutathione
Source sentences
Summary
Erythema, edema, and ecchymosis was not significantly different among two cocktails (P-value > 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics.
Summary · context
Then, patients underwent melasma therapy using Cocktail A (TA 4 mg/mL; vitamin C 3% and glutathione 2%) on their right half of the face and Cocktail B (TA 4 mg/mL and vitamin C 3%) on their left half of the face, with mesotherapy technique.
Report a problemFND-3073561105

Studies that did not test the peptide alone1

In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Glutathione.

05HumanNot a test of Glutathione aloneRandomized controlled trialEfficacy outcome
In patients with melasma, cocktail A containing glutathione, tranexamic acid and vitamin C reduced mMASI by 3.046 ± 1.25 from baseline.
In plain wordsIn patients with melasma, the glutathione, tranexamic acid and vitamin C cocktail reduced skin pigmentation scores from baseline.
Peptide
Glutathione
Outcome
DecreasemMASI change with cocktail A
Study
n = 30
Outcome group
Pigmentation · Skin and wound
Measurements
mMASI decrease
3.046 NA
cocktail A
Reported ± uncertainty for mean mMASI decrease
1.25 NA
cocktail A; right side; decrease from baseline at 12 weeks; uncertainty type not stated
P value for mMASI change from baseline
< 0.001 NA
cocktail A; right side; baseline versus 12 weeks
Source sentences
Summary
Mean of mMASI in left side had decrease of 1.82 ± 0.88 (P-value < 0.001) and in right side had decrease of 3.046 ± 1.25 (P-value < 0.001) from base line.
2 context sentences(design, population, supporting numbers)
Summary · context
This is a randomized clinical trial study conducted on 30 patients referred to Dermatology Clinics.
Summary · context
Then, patients underwent melasma therapy using Cocktail A (TA 4 mg/mL; vitamin C 3% and glutathione 2%) on their right half of the face and Cocktail B (TA 4 mg/mL and vitamin C 3%) on their left half of the face, with mesotherapy technique.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-3073561101

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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