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Study · In vitro (cells) · 2019

7 results

NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes.

Ramírez D, Saba J, Turati J, Carniglia L, Imsen M, Mohn C, Scimonelli T, Durand D, Caruso C, Lasaga M

Journal of neuroendocrinology20 Feb 2019Cited by 14 (Europe PMC)

PMID30712280 (opens in a new tab)DOI10.1111/jne.12673 (opens in a new tab)PepBankPUB-30712280
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In primary astrocytes, NDP-MSH decreased reactive oxygen species production induced by palmitic acid.

    In plain wordsIn cultured astrocytes, NDP-MSH lowered the reactive oxygen species that palmitic acid caused.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreasePA-induced reactive oxygen species production
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that NDP-MSH treatment decreased PA-induced reactive oxygen species production in astrocytes, an effect blocked by the MC4R inhibitor JKC363.
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  2. 02LabIn vitro (cells)Mechanism

    In primary astrocytes, the MC4R inhibitor JKC363 blocked the NDP-MSH reduction of palmitic acid-induced reactive oxygen species.

    In plain wordsIn cultured astrocytes, blocking the MC4R receptor removed the antioxidant effect of NDP-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBlock of NDP-MSH effect on ROS by MC4R inhibitor
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that NDP-MSH treatment decreased PA-induced reactive oxygen species production in astrocytes, an effect blocked by the MC4R inhibitor JKC363.
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  3. 03LabIn vitro (cells)Mechanism

    In primary astrocytes, NDP-MSH abolished the nuclear translocation of Nrf2 induced by palmitic acid.

    In plain wordsIn cultured astrocytes, NDP-MSH stopped palmitic acid from moving Nrf2 into the cell nucleus.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNrf2 nuclear translocation induced by PA
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH abolished nuclear translocation of Nrf2 induced by PA
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  4. 04LabIn vitro (cells)Efficacy outcome

    In primary astrocytes, NDP-MSH blocked the inhibitory effect of palmitic acid on superoxide dismutase activity.

    In plain wordsIn cultured astrocytes, NDP-MSH prevented palmitic acid from lowering the activity of the antioxidant enzyme SOD.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseSOD activity in the presence of PA
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    blocked the inhibitory effect of PA on superoxide dismutase (SOD) activity and glutathione levels
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  5. 05LabIn vitro (cells)Efficacy outcome

    In primary astrocytes, NDP-MSH blocked the inhibitory effect of palmitic acid on glutathione levels.

    In plain wordsIn cultured astrocytes, NDP-MSH prevented palmitic acid from lowering glutathione levels.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseGlutathione levels in the presence of PA
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    blocked the inhibitory effect of PA on superoxide dismutase (SOD) activity and glutathione levels
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  6. 06LabIn vitro (cells)Efficacy outcome

    In primary astrocytes, NDP-MSH alone increased the activity of superoxide dismutase.

    In plain wordsIn cultured astrocytes, NDP-MSH on its own raised the activity of the antioxidant enzyme SOD.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseSOD activity with NDP-MSH alone
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while it also per se increased activity of SOD and γ-glutamate cysteine ligase (γ-GCL) antioxidant enzymes.
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.
  7. 07LabIn vitro (cells)Efficacy outcome

    In primary astrocytes, NDP-MSH alone increased the activity of the antioxidant enzyme gamma-glutamate cysteine ligase.

    In plain wordsIn cultured astrocytes, NDP-MSH on its own raised the activity of the antioxidant enzyme gamma-GCL.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Increasegamma-GCL activity with NDP-MSH alone
    Study

    n: not reported in source

    Primary astrocytes exposed to palmitic acid (PA)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while it also per se increased activity of SOD and γ-glutamate cysteine ligase (γ-GCL) antioxidant enzymes.
    1 context sentence
    Summary · context
    The aim of this study was to investigate whether melanocortins could alleviate oxidative stress induced by a high fat diet (HFD) model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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