[USING CORTEXIN TO MANAGE THE CONSEQUENCES OF PERINATAL HYPOXIC BRAIN INJURY IN INFANT RATS].

Kuznetsov SV, Kuznetsova NN

Zhurnal evoliutsionnoi biokhimii i fiziologii1 Mar 2016

PMID30695499PepBankPUB-30695499

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In infant rats with brain injury, cortexin transiently improved EMG spectral structure on day 10.
In plain wordsIn rats with brain injury, cortexin briefly improved muscle electrical spectral patterns on day 10.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseEMG spectral structure at day 10
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
EMG of the rats.treated with cortexin showed a transient improvement of its spect- ral structure but not of the amplitude on day 10.
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
Report a problemFND-3069549901
02AnimalAnimal study (in vivo)Efficacy outcome
In infant rats with brain injury, cortexin did not improve EMG amplitude on day 10.
In plain wordsIn rats with brain injury, cortexin did not improve muscle electrical amplitude on day 10.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
Direction not reportedEMG amplitude at day 10
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
EMG of the rats.treated with cortexin showed a transient improvement of its spect- ral structure but not of the amplitude on day 10.
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
Report a problemFND-3069549902
03AnimalAnimal study (in vivo)Efficacy outcome
In infant rats with brain injury, the earlier EMG benefit of cortexin was absent on day 30.
In plain wordsIn rats with brain injury, the earlier muscle electrical benefit of cortexin was absent on day 30.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
Direction not reportedEMG benefit at day 30
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
On day 30 the positive effect of cortexin, as observed earlier, was not revealed.
4 context sentences(design, population, supporting numbers)
Summary · context
EMG of the rats.treated with cortexin showed a transient improvement of its spect- ral structure but not of the amplitude on day 10.
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
Report a problemFND-3069549903
04AnimalAnimal study (in vivo)Efficacy outcome
In infant rats with brain injury, cortexin improved vagosympathetic balance at day 30 compared with untreated injured rats.
In plain wordsIn rats with brain injury, cortexin improved autonomic balance at day 30 compared with untreated injured rats.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseVagosympathetic balance at day 30
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Comparator
Untreated injured rats
Outcome group
Heart function · Cardiovascular
Studied dose
1 mg/kg · intraperitoneal · 10 daysAs given in this study (rat).
Source sentences
Summary
On day 30 cortexin treatment gave a positive effect whereas in non-tre- ated rats a shift of vagosympathetic balance occurred towards the prevalence of humoral, metabolic, and sympathetic influences.
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
Report a problemFND-3069549907
05AnimalAnimal study (in vivo)Safety outcome
In intact infant rats, cortexin caused appreciable disturbances of vagosympathetic balance.
In plain wordsIn rats without injury, cortexin disturbed autonomic balance.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseVagosympathetic balance disturbance in intact rats
Study
ratn: not reported in source
Intact infant rats
Outcome group
Adverse events · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Administration of cortexin to intact infant rats leads to appreciable disturban- ces of vagosympathetic balance, heart rhythm, and, to a lesser extent, respiration rhythm and may cause steady disturbances of somatic and autonomic nervous system activity.
Report a problemFND-3069549908
06AnimalAnimal study (in vivo)Safety outcome
In intact infant rats, cortexin caused appreciable heart rhythm disturbances.
In plain wordsIn rats without injury, cortexin disturbed heart rhythm.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseHeart rhythm disturbance in intact rats
Study
ratn: not reported in source
Intact infant rats
Outcome group
Adverse events · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Administration of cortexin to intact infant rats leads to appreciable disturban- ces of vagosympathetic balance, heart rhythm, and, to a lesser extent, respiration rhythm and may cause steady disturbances of somatic and autonomic nervous system activity.
Report a problemFND-3069549909
07AnimalAnimal study (in vivo)Safety outcome
In intact infant rats, cortexin disturbed respiration rhythm to a lesser extent than vagosympathetic balance and heart rhythm.
In plain wordsIn rats without injury, cortexin disturbed breathing rhythm less than autonomic balance and heart rhythm.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseRespiration rhythm disturbance in intact rats
Study
ratn: not reported in source
Intact infant rats
Outcome group
Adverse events · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
Administration of cortexin to intact infant rats leads to appreciable disturban- ces of vagosympathetic balance, heart rhythm, and, to a lesser extent, respiration rhythm and may cause steady disturbances of somatic and autonomic nervous system activity.
Report a problemFND-3069549910

Studies that did not test the peptide alone3

In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cortexin (cortical polypeptide complex).

08AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome
In infant rats, respiration rate was higher after brain injury in both cortexin-treated and untreated groups than in controls.
In plain wordsIn rats, breathing was faster in both cortexin-treated and untreated injury groups than in controls.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseRespiration rate
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Comparator
Control rats
Outcome group
Respiratory function · Respiratory
Source sentences
Summary
Respiration rate in both treated and non-treated rats was higher than in the control.
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-3069549904
09AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome
In infant rats, heart beat rate was unaltered after brain injury, including in cortexin-treated animals.
In plain wordsIn rats, heart rate was unchanged after brain injury, including in cortexin-treated animals.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
Direction not reportedHeart beat rate
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Heart beat rate in operated rats was not altered
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-3069549905
10AnimalNot a test of Cortexin (cortical polypeptide complex) aloneAnimal study (in vivo)Efficacy outcome
In infant rats after trauma, parasympathetic predominance increased in both cortexin-treated and untreated groups at day 10.
In plain wordsIn rats after injury, parasympathetic influence increased in both cortexin-treated and untreated groups at day 10.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseVagosympathetic balance at day 10
Study
ratn: not reported in source
Perinatal hypoxic-ischemic brain injury
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
The analysis of heart rate variability (HRV) showed that 10 days after trauma both treated and non-treated rats had a statistically significant shift of vagosympathetic balance towards the prevalence of parasympathetic influences.
3 context sentences(design, population, supporting numbers)
Summary · context
Ischemic brain injury was induced in 7-day-old rats by ligation of the left general carotid artery (under ether anesthesia) followed by keeping the animals in hypoxic gas cham- ber containing 8 % of oxygen and 92 % of nitrogen (day 1 of the experiment).
Summary · context
One hour after the exposure to hypoxic conditions the rats of the experimental group were treated with intraperitoneal injections of cortexin at a dose of 1 mg/kg.
Summary · context
The drug was injected daily for 10 days.
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).
Report a problemFND-3069549906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.