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Study · Not a test of the peptide alone · 2019

3 results

Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family.

Nan A, Chen L, Zhang N, Jia Y, Li X, Zhou H, Ling Y, Wang Z, Yang C, Liu S, Jiang Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany)16 Nov 2018Cited by 87 (Europe PMC)

PMID30693177 (opens in a new tab)PMCIDPMC6343086 (opens in a new tab)DOI10.1002/advs.201800654 (opens in a new tab)PepBankPUB-30693177
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Summary

circNOL10 is a circular RNA expressed at low levels in lung cancer, though its functions in lung cancer remain unknown. Here, the function and molecular mechanism of circNOL10 in lung cancer development are investigated using in vitro and in vivo studies, and it is shown that circNOL10 significantly inhibits the development of lung cancer and that circNOL10 expression is co-regulated by methylation of its parental gene Pre-NOL10 and by splicing factor epithelial splicing regulatory protein 1 (ESRP1). circNOL10 promotes the expression of transcription factor sex comb on midleg-like 1 (SCML1) by inhibiting transcription factor ubiquitination and thus also affects regulation of the humanin (HN) polypeptide family by SCML1. circNOL10 also affects mitochondrial function through regulating the humanin polypeptide family and affecting multiple signaling pathways, ultimately inhibiting cell proliferation and cell cycle progression, and promoting the apoptosis of lung cancer cells, thereby inhibiting lung cancer development. This study investigates the functions and molecular mechanisms of circNOL10 in the development of lung cancer and reveals its involvement in the transcriptional regulation of the HN polypeptide family by SCML1. The results also demonstrate the inhibitory effect of HN on lung cancer cells growth. These findings may identify novel targets for the molecular therapy of lung cancer.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In lung cancer cells, HN showed an inhibitory effect on cell growth, with HN delivery not described in the abstract.

    In plain wordsIn lab tests on lung cancer cells, humanin slowed cell growth. The abstract does not say how humanin was supplied.

    Peptide
    Humanin
    Outcome
    DecreaseLung cancer cell growth with HN
    Study

    n: not reported in source

    Lung cancer cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    The results also demonstrate the inhibitory effect of HN on lung cancer cells growth.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In lung cancer models, circNOL10 promoted SCML1 expression and thereby affected regulation of the humanin polypeptide family.

    In plain wordsIn lung cancer models, a circular RNA called circNOL10 changed how the humanin peptide family is controlled.

    Peptide
    Humanin
    Outcome
    Not applicableRegulation of the humanin polypeptide family by circNOL10 via SCML1
    Study

    n: not reported in source

    Lung cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    circNOL10 promotes the expression of transcription factor sex comb on midleg-like 1 (SCML1) by inhibiting transcription factor ubiquitination and thus also affects regulation of the humanin (HN) polypeptide family by SCML1

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In lung cancer models, circNOL10 affected mitochondrial function through regulation of the humanin polypeptide family.

    In plain wordsIn lung cancer models, circNOL10 changed mitochondrial function by acting on the humanin peptide family.

    Peptide
    Humanin
    Outcome
    Not applicableMitochondrial function via the humanin polypeptide family
    Study

    n: not reported in source

    Lung cancer cells
    Outcome group
    Mitochondrial function · Cancer

    Source sentences

    Summary
    circNOL10 also affects mitochondrial function through regulating the humanin polypeptide family and affecting multiple signaling pathways

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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