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Study · Animal study (in vivo) · mouse · 2019

11 results

Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment.

Zaman F, Zhao Y, Celvin B, Mehta HH, Wan J, Chrysis D, Ohlsson C, Fadeel B, Cohen P, Sävendahl L

FASEB journal : official publication of the Federation of American Societies for Experimental Biology18 Jan 2019Cited by 34 (Europe PMC)

PMID30657335 (opens in a new tab)PMCIDPMC6988867 (opens in a new tab)DOI10.1096/fj.201801741r (opens in a new tab)PepBankPUB-30657335
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice, HN treatment prevented glucocorticoid-induced bone growth impairment.

    In plain wordsIn mice, HN treatment prevented the bone growth impairment that glucocorticoids caused.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced bone growth impairment
    Study

    mousen: not reported in source

    Wild-type mice treated with glucocorticoids
    Comparator
    Glucocorticoid without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice, HN treatment prevented glucocorticoid-induced chondrocyte apoptosis.

    In plain wordsIn mice, HN treatment prevented the death of growth plate cartilage cells that glucocorticoids caused.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced chondrocyte apoptosis
    Study

    mousen: not reported in source

    Wild-type mice treated with glucocorticoids
    Comparator
    Glucocorticoid without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    HN prevented the glucocorticoid-induced suppression of chondrocyte proliferation.

    In plain wordsIn the animal and bone models tested, HN prevented the glucocorticoid-induced slowing of cartilage cell growth.

    Peptide
    Humanin
    Outcome
    IncreaseGlucocorticoid-induced suppression of chondrocyte proliferation
    Study

    n: not reported in source

    Comparator
    Glucocorticoid without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GC-induced suppression of chondrocyte proliferation was also prevented by HN.
  4. 04AnimalAnimal study (in vivo)Mechanism

    Glucocorticoid reduced Indian Hedgehog expression in growth plates of wild-type mice, but not in HN-treated wild-type animals.

    In plain wordsIn mice, glucocorticoids lowered a bone growth signal in growth plates, but not in mice treated with HN.

    Peptide
    Humanin
    Outcome
    IncreaseIndian Hedgehog expression in growth plate
    Study

    mousen: not reported in source

    Growth plates of glucocorticoid-treated wild-type mice
    Comparator
    Glucocorticoid without HN
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, GC treatment reduced Indian Hedgehog expression in growth plates of wild-type mice but not in HN overexpressing mice or HN-treated wild-type animals.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    HN did not interfere with the desired anti-inflammatory effects of glucocorticoids.

    In plain wordsIn the models tested, HN did not block the anti-inflammatory effects of glucocorticoids.

    Peptide
    Humanin
    Outcome
    No significant changeAnti-inflammatory effects of glucocorticoids
    Study

    n: not reported in source

    Comparator
    Glucocorticoid without HN
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, HN did not interfere with the desired anti-inflammatory effects of GCs.
  6. 06LabEx vivo tissueEfficacy outcome

    In cultured rat metatarsal bones, HN treatment prevented glucocorticoid-induced bone growth impairment.

    In plain wordsIn lab tests on rat bones, HN treatment prevented the bone growth impairment that glucocorticoids caused.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced bone growth impairment
    Study

    ratn: not reported in source

    Cultured rat metatarsal bones treated with glucocorticoids
    Comparator
    Glucocorticoid without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.
  7. 07LabEx vivo tissueEfficacy outcome

    In cultured rat metatarsal bones, HN treatment prevented glucocorticoid-induced chondrocyte apoptosis.

    In plain wordsIn lab tests on rat bones, HN treatment prevented the cartilage cell death that glucocorticoids caused.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced chondrocyte apoptosis
    Study

    ratn: not reported in source

    Cultured rat metatarsal bones treated with glucocorticoids
    Comparator
    Glucocorticoid without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.
  8. 08LabEx vivo tissueEfficacy outcome

    In cultured rat metatarsal bones, HN prevented the growth suppression caused by the Hedgehog antagonist vismodegib.

    In plain wordsIn lab tests on rat bones, HN prevented the slowing of bone growth caused by a Hedgehog-blocking drug.

    Peptide
    Humanin
    Outcome
    IncreaseVismodegib-induced suppression of metatarsal bone growth
    Study

    ratn: not reported in source

    Cultured rat metatarsal bones treated with vismodegib
    Comparator
    Vismodegib without HN
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A Hedgehog (Hh) antagonist, vismodegib, was found to suppress the growth of cultured rat metatarsal bones, and this effect was also prevented by HN.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 09AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice that overexpress the humanin gene, glucocorticoid-induced bone growth impairment was prevented.

    In plain wordsIn mice bred to make extra humanin, glucocorticoids did not impair bone growth.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced bone growth impairment
    Study

    mousen: not reported in source

    HN overexpressing transgenic mice treated with glucocorticoids
    Comparator
    Wild-type mice with glucocorticoids
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 10AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice that overexpress the humanin gene, glucocorticoid-induced chondrocyte apoptosis was prevented.

    In plain wordsIn mice bred to make extra humanin, glucocorticoids did not cause growth plate cartilage cell death.

    Peptide
    Humanin
    Outcome
    DecreaseGlucocorticoid-induced chondrocyte apoptosis
    Study

    mousen: not reported in source

    HN overexpressing transgenic mice treated with glucocorticoids
    Comparator
    Wild-type mice with glucocorticoids
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 11AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Glucocorticoid reduced Indian Hedgehog expression in growth plates of wild-type mice but not in HN overexpressing mice.

    In plain wordsIn mice bred to make extra humanin, glucocorticoids did not lower a bone growth signal in growth plates.

    Peptide
    Humanin
    Outcome
    IncreaseIndian Hedgehog expression in growth plate
    Study

    mousen: not reported in source

    Growth plates of HN overexpressing mice treated with glucocorticoids
    Comparator
    Wild-type mice with glucocorticoids
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Furthermore, GC treatment reduced Indian Hedgehog expression in growth plates of wild-type mice but not in HN overexpressing mice or HN-treated wild-type animals.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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