In rats with endometriosis, diphereline most strongly suppressed implant growth across the evaluated parameters compared with the other treatment groups.
In plain wordsIn rats with endometriosis, diphereline suppressed implant growth most strongly across the evaluated measures compared with the other treatment groups.
- Outcome
- DecreaseEndometrial implant growth across evaluated parameters
- Study
ratn: not reported in source
autotransplanted endometrial implants- Comparator
- normal saline, licorice extract and celecoxib
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 3 mg/kg · intramuscular · 6 weeksAs given in this study (rat).
Source sentences
Diphereline was the most potent agent for suppressing the growth of endometrial implants in terms of all of the above-mentioned parameters.
3 context sentences(design, population, supporting numbers)
The purpose of this study was to compare the effects of Glycyrrhiza glabra (Licorice), a cyclooxygenase- 2 inhibitor (Celecoxib) and a gonadotropin-releasing hormone analog (Diphereline®), with a control group on endometrial implants in rats.
In this experimental study, endometriosis was induced in rats by auto transplantation and after confirmation, the rats were divided into 4 groups that were treated for 6 weeks with normal saline (0.5 ml/day, orally), licorice extract (3000 mg/kg/day, orally), celecoxib (50 mg/kg, twice a day, orally) or diphereline (3 mg/kg, intramuscularly).
At the end of treatments, the mean area, volume, histopathology and hemosiderin-laden macrophage (HLM) counts of the endometrial implants were evaluated and compared among the four groups.