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Study · Animal study (in vivo) · rat · 2018

7 results

Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine.

Drmic D, Samara M, Vidovic T, Malekinusic D, Antunovic M, Vrdoljak B, Ruzman J, Milkovic Perisa M, Horvat Pavlov K, Jeyakumar J, Seiwerth S, Sikiric P

World journal of gastroenterology1 Dec 2018Cited by 40 (Europe PMC)

PMID30622376 (opens in a new tab)PMCIDPMC6319139 (opens in a new tab)DOI10.3748/wjg.v24.i48.5462 (opens in a new tab)PepBankPUB-30622376
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with perforated cecum, a BPC‑157 bath markedly increased vessel presentation compared with saline controls.

    In plain wordsIn rats with a cecum injury, a BPC‑157 bath markedly increased blood vessels at the injury compared with saline.

    Peptide
    BPC-157
    Outcome
    IncreaseVessel presentation at the defect
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    Saline bath
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal.
    1 context sentence
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with perforated cecum, a BPC‑157 bath noticeably narrowed the defect.

    In plain wordsIn rats with a cecum injury, a BPC‑157 bath noticeably narrowed the defect compared with saline.

    Peptide
    BPC-157
    Outcome
    IncreaseDefect narrowing
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    Saline bath
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal.
    1 context sentence
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with perforated cecum, a BPC‑157 bath shortened the bleeding time.

    In plain wordsIn rats with a cecum injury, a BPC‑157 bath shortened bleeding compared with saline.

    Peptide
    BPC-157
    Outcome
    DecreaseBleeding time
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    Saline bath
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal.
    1 context sentence
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with perforated cecum, MDA levels increased after a saline bath but remained normal after a BPC‑157 bath.

    In plain wordsIn rats with a cecum injury, a BPC‑157 bath kept the oxidative stress marker MDA normal, unlike saline.

    Peptide
    BPC-157
    Outcome
    DecreaseCecum tissue MDA level
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    Saline bath
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    Post-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO-levels decreased.
    2 context sentences
    Summary · context
    BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal.
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with perforated cecum, NO levels decreased after a saline bath but remained normal after a BPC‑157 bath.

    In plain wordsIn rats with a cecum injury, a BPC‑157 bath kept nitric oxide normal, unlike saline.

    Peptide
    BPC-157
    Outcome
    IncreaseCecum tissue NO level
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    Saline bath
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    Post-injury, during/after a saline bath, the number of vessels was significantly reduced, the defect was slightly narrowed, bleeding was significant and MDA-levels increased and NO-levels decreased.
    2 context sentences
    Summary · context
    BPC 157 bath: the vessel presentation was markedly increased, the defect was noticeably narrowed, the bleeding time was shortened and MDA- and NO-levels remained normal.
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with perforated cecum, vessel presentation with BPC‑157 plus L-NAME, L-arginine or both was similar to that with BPC‑157 alone.

    In plain wordsIn rats with a cecum injury, adding L-NAME or L-arginine to BPC‑157 gave a similar vessel response as BPC‑157 alone.

    Peptide
    BPC-157
    Outcome
    No significant changeVessel presentation with BPC 157 plus NO-agents
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    BPC 157 alone
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    In combination, mutual counteraction occurred (L-NAME + L-arginine) or the presentation was similar to that of BPC 157 rats (BPC 157 + L-NAME; BPC 157 + L-arginine; BPC 157 + L-NAME + L-arginine), except the defect did not change.
    1 context sentence
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with perforated cecum, the defect did not change with BPC‑157 combined with L-NAME, L-arginine or both, whereas the presentation was otherwise similar to BPC‑157 alone.

    In plain wordsIn rats with a cecum injury, the defect did not change when BPC‑157 was combined with L-NAME or L-arginine.

    Peptide
    BPC-157
    Outcome
    No significant changeDefect size with BPC 157 plus NO-agents
    Study

    ratn: not reported in source

    Rat perforated cecum injury
    Comparator
    BPC 157 alone
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg · bathAs given in this study (rat).

    Source sentences

    Summary
    In combination, mutual counteraction occurred (L-NAME + L-arginine) or the presentation was similar to that of BPC 157 rats (BPC 157 + L-NAME; BPC 157 + L-arginine; BPC 157 + L-NAME + L-arginine), except the defect did not change.
    1 context sentence
    Summary · context
    To study the counteraction of perforated cecum lesion using BPC 157 and nitric oxide (NO) system agents.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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