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Study · Not a test of the peptide alone · 2019

4 results

Micro-solid phase extraction and LC-MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study.

Ren T, Zhang Z, Fawcett JP, Sun D, Gu J

Journal of pharmaceutical and biomedical analysis26 Dec 2018Cited by 13 (Europe PMC)

PMID30599277 (opens in a new tab)DOI10.1016/j.jpba.2018.12.039 (opens in a new tab)PepBankPUB-30599277
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Other

    In rat plasma assays, micro-solid phase extraction concentrated samples for triptorelin analysis without evaporation or reconstitution.

    In plain wordsIn lab tests, sample preparation for triptorelin analysis concentrated rat plasma samples without evaporation or reconstitution.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableSample concentration by micro-solid phase extraction
    Study

    ratn: not reported in source

    rat plasma analytical assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Sample preparation by μ-SPE achieved sample concentration without the need for evaporation and reconstitution steps.
    1 context sentence
    Summary · context
    We have overcome these issues using micro-solid phase extraction (μ-SPE) on Oasis® HLB 96-well μElution plates followed by LC-MS3.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Other

    In rat plasma assays, LC-MS detection of triptorelin showed no significant matrix interference at the analyte retention time.

    In plain wordsIn lab tests, rat plasma did not significantly interfere with triptorelin detection at its retention time.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableMatrix interference
    Study

    ratn: not reported in source

    rat plasma analytical assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Detection by LC-MS3 showed no significant matrix interference at the retention time of analyte
    1 context sentence
    Summary · context
    We have overcome these issues using micro-solid phase extraction (μ-SPE) on Oasis® HLB 96-well μElution plates followed by LC-MS3.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  3. 03LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Other

    In rat plasma assays, the triptorelin method achieved a lower quantitation limit of 10 pg/mL.

    In plain wordsIn lab tests, the method measured triptorelin in rat plasma down to 10 pg/mL.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableLower limit of quantitation
    Study

    ratn: not reported in source

    rat plasma analytical assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Lower limit of quantitation
    10 pg/mL
    rat plasma

    Source sentences

    Summary
    achieved high sensitivity (lower limit of quantitation 10 pg/mL)
    1 context sentence
    Summary · context
    We have overcome these issues using micro-solid phase extraction (μ-SPE) on Oasis® HLB 96-well μElution plates followed by LC-MS3.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  4. 04LabNot a test of Triptorelin (Trelstar, Decapeptyl) aloneIn vitro (cell-free)Other

    In rat plasma assays, the triptorelin method showed good linearity over 10-3000 pg/mL.

    In plain wordsIn lab tests, the triptorelin assay showed good linearity over 10-3000 pg/mL in rat plasma.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableAssay linearity
    Study

    ratn: not reported in source

    rat plasma analytical assay
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Linear range
    10 to 3000 pg/mL
    rat plasma

    Source sentences

    Summary
    good linearity in the range 10-3000 pg/mL.
    1 context sentence
    Summary · context
    We have overcome these issues using micro-solid phase extraction (μ-SPE) on Oasis® HLB 96-well μElution plates followed by LC-MS3.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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