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Study · Animal study (in vivo) · rat · 2018

8 results

Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine.

Amic F, Drmic D, Bilic Z, Krezic I, Zizek H, Peklic M, Klicek R, Pajtak A, Amic E, Vidovic T, Rakic M, Milkovic Perisa M and 7 more

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Horvat Pavlov K, Kokot A, Tvrdeic A, Boban Blagaic A, Zovak M, Seiwerth S, Sikiric P

World journal of gastroenterology1 Dec 2018Cited by 39 (Europe PMC)

PMID30598581 (opens in a new tab)PMCIDPMC6305534 (opens in a new tab)DOI10.3748/wjg.v24.i47.5366 (opens in a new tab)PepBankPUB-30598581
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ligation of the superior anterior pancreaticoduodenal vein, BPC‑157 strongly attenuated mucosal lesions of the duodenum.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 strongly reduced damage to the duodenal lining compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseDuodenal mucosal lesions
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Unlike the severe course in the SAPDV-ligated controls, after BPC 157 application, the rats exhibited strong attenuation of the mucosal lesions
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ligation of the superior anterior pancreaticoduodenal vein, BPC‑157 strongly attenuated serosal congestion.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 strongly reduced blood pooling in the duodenal outer layer compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseDuodenal serosal congestion
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Unlike the severe course in the SAPDV-ligated controls, after BPC 157 application, the rats exhibited strong attenuation of the mucosal lesions and serosal congestion
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with vein ligation, BPC‑157 improved vessel presentation and increased interconnections.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 improved blood vessel appearance and increased connections between vessels.

    Peptide
    BPC-157
    Outcome
    IncreaseVessel presentation and interconnections
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    improved vessel presentation, increased interconnections
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with vein ligation, BPC‑157 increased vessel branching by more than 60% from the initial value.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 increased vessel branching by more than 60%.

    Peptide
    BPC-157
    Outcome
    IncreaseVessel branching
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Measurements

    Increase in branching
    > 60%
    from initial value

    Source sentences

    Summary
    increased branching by more than 60% from the initial value, the IAPDV and SMV were not congested.
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with vein ligation, the inferior anterior pancreaticoduodenal vein and superior mesenteric vein were not congested after BPC‑157.

    In plain wordsIn rats with a blocked duodenal vein, the bypass veins were not congested after BPC‑157.

    Peptide
    BPC-157
    Outcome
    DecreaseVenous congestion of IAPDV and SMV
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    the IAPDV and SMV were not congested.
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In vein-ligated rats, those given BPC‑157 with L-NAME, L-arginine or both appeared similar to rats given BPC‑157 alone.

    In plain wordsIn rats with a blocked duodenal vein, adding L-NAME or L-arginine to BPC‑157 gave a result similar to BPC‑157 alone.

    Peptide
    BPC-157
    Outcome
    No significant changeLesions with BPC 157 plus NO-agents
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    BPC 157 alone
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    With BPC 157, all SAPDV-ligated rats receiving L-NAME and/or L-arginine appeared similar to the rats treated with BPC 157 alone.
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In vein-ligated rats, BPC‑157 normalized nitric oxide levels in duodenal tissue.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 returned nitric oxide levels in the duodenum to normal.

    Peptide
    BPC-157
    Outcome
    DecreaseDuodenal NO level
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Also, BPC 157 in SAPDV-ligated rats normalized levels of NO and MDA, two oxidative stress markers, in duodenal tissues.
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In vein-ligated rats, BPC‑157 normalized malondialdehyde levels, an oxidative stress marker, in duodenal tissue.

    In plain wordsIn rats with a blocked duodenal vein, BPC‑157 returned the oxidative stress marker MDA in the duodenum to normal.

    Peptide
    BPC-157
    Outcome
    DecreaseDuodenal MDA level
    Study

    ratn: not reported in source

    Rat superior anterior pancreaticoduodenal vein ligation
    Comparator
    SAPDV-ligated controls
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg or 10 ng/kg · bath at ligated vein site or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Also, BPC 157 in SAPDV-ligated rats normalized levels of NO and MDA, two oxidative stress markers, in duodenal tissues.
    1 context sentence
    Summary · context
    To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide (NO) system involvement.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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