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Study · Animal study (in vivo) · mouse · 2018

2 results

Contrast-enhanced ultrasound for ovary assessment in a murine model: preliminary findings on the protective role of a gonadotropin-releasing hormone analogue from chemotherapy-induced ovarian damage.

Venturini M, Bergamini A, Perani L, Sanchez AM, Rossi EG, Colarieti A, Petrone M, De Cobelli F, Del Maschio A, Viganò P, Mangili G, Candiani M, Tacchetti C, Esposito A

European radiology experimental19 Dec 2018Cited by 5 (Europe PMC)

PMID30564987 (opens in a new tab)PMCIDPMC6298912 (opens in a new tab)DOI10.1186/s41747-018-0076-z (opens in a new tab)PepBankPUB-30564987
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Summary

The prolonged, gonadotoxic effect of chemotherapy can finally lead to infertility in female cancer survivors. There is controversial evidence regarding the protective role of gonadotropin-releasing hormone analogue (GnRH-a) on chemotherapy-induced ovarian damage. In the present study on a murine model, ultrasound (US) and contrast-enhanced US (CEUS) were firstly used to characterise ovarian glands in normal conditions to validate a preclinical model. In addition, preliminary findings were obtained on anatomical and vascular ovarian changes induced by GnRH-a based on decapeptyl administration. Ovaries were accurately assessed with US and CEUS in a murine model placed in prone position, providing quantitative and reproducible information. Ovaries were identified in 40/40 cases and CEUS analysis was successfully performed in 20/20 cases with 100% technical success. A statistically significant increase of the diameter of the dominant follicle at US and a statistically significant reduced vascularisation at CEUS in decapeptyl-treated mice compared to untreated control mice were recorded. Further studies using US and CEUS in the murine model combining GnRH-a and chemotherapeutic agents will be needed to obtain more translational information useful for clinical practice.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, decapeptyl increased dominant follicle diameter compared with untreated controls.

    In plain wordsIn mice, decapeptyl increased dominant follicle diameter compared with untreated controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseDominant follicle diameter
    Study

    mousen: not reported in source

    Murine ovarian ultrasound model
    Comparator
    Untreated mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A statistically significant increase of the diameter of the dominant follicle at US and a statistically significant reduced vascularisation at CEUS in decapeptyl-treated mice compared to untreated control mice were recorded.
    2 context sentences
    Summary · context
    In the present study on a murine model, ultrasound (US) and contrast-enhanced US (CEUS) were firstly used to characterise ovarian glands in normal conditions to validate a preclinical model.
    Summary · context
    In addition, preliminary findings were obtained on anatomical and vascular ovarian changes induced by GnRH-a based on decapeptyl administration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, decapeptyl reduced ovarian vascularisation compared with untreated controls.

    In plain wordsIn mice, decapeptyl reduced ovarian blood supply compared with untreated controls.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvarian vascularisation
    Study

    mousen: not reported in source

    Murine ovarian ultrasound model
    Comparator
    Untreated mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A statistically significant increase of the diameter of the dominant follicle at US and a statistically significant reduced vascularisation at CEUS in decapeptyl-treated mice compared to untreated control mice were recorded.
    2 context sentences
    Summary · context
    In the present study on a murine model, ultrasound (US) and contrast-enhanced US (CEUS) were firstly used to characterise ovarian glands in normal conditions to validate a preclinical model.
    Summary · context
    In addition, preliminary findings were obtained on anatomical and vascular ovarian changes induced by GnRH-a based on decapeptyl administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

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  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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