Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats.

Saito R, Tanaka K, Nishimura H, Nishimura K, Sonoda S, Ueno H, Motojima Y, Yoshimura M, Maruyama T, Yamamoto Y, Kusuhara K, Ueta Y

Peptides16 Dec 2018Cited by 36 (Europe PMC)

PMID30562556DOI10.1016/j.peptides.2018.12.003PepBankPUB-30562556

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular KP-10 at 6.0 µg decreased cumulative food intake 0.5-3 hours after injection compared with vehicle.
In plain wordsIn rats, kisspeptin‑10 injected into the brain reduced food intake compared with vehicle.
Peptide
Kisspeptin-10
Outcome
DecreaseCumulative food intake 0.5-3 h after icv KP-10
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
6.0 µg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Cumulative food intake was remarkably decreased 0.5-3 h after icv administration of KP-10 (6.0 μg) compared to the vehicle treated and the KP-10 (3.8 μg) treated group.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255601
02AnimalAnimal study (in vivo)Efficacy outcome
In male rats, intracerebroventricular KP-10 at 6.0 µg decreased cumulative food intake more than KP-10 at 3.8 µg.
In plain wordsIn rats, the higher brain dose of kisspeptin‑10 reduced food intake more than the lower dose.
Peptide
Kisspeptin-10
Outcome
DecreaseCumulative food intake, 6.0 µg versus 3.8 µg KP-10
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
KP-10 3.8 µg
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
6.0 µg · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Cumulative food intake was remarkably decreased 0.5-3 h after icv administration of KP-10 (6.0 μg) compared to the vehicle treated and the KP-10 (3.8 μg) treated group.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255602
03AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the supraoptic nucleus.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the supraoptic nucleus.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, supraoptic nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255603
04AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the paraventricular nucleus.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the paraventricular nucleus.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, paraventricular nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255604
05AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the arcuate nucleus.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the arcuate nucleus.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, arcuate nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255605
06AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the dorsal raphe nucleus.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the dorsal raphe nucleus.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, dorsal raphe nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255606
07AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the locus coeruleus.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the locus coeruleus.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, locus coeruleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255607
08AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 increased the number of nesfatin-1 neurons expressing Fos in the nucleus tractus solitarius.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more nesfatin-1 neurons in the nucleus tractus solitarius.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in nesfatin-1 neurons, nucleus tractus solitarius
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
The icv administration of KP-10 significantly increased the number of nesfatin-1-ir neurons expressing Fos in the supraoptic nucleus (SON), paraventricular nucleus (PVN), arcuate nucleus (ARC), dorsal raphe nucleus, locus coeruleus, and nucleus tractus solitarius.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255608
09AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 raised the percentage of oxytocin neurons expressing Fos in the supraoptic nucleus compared with vehicle.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more oxytocin neurons in the supraoptic nucleus than vehicle did.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in oxytocin neurons, supraoptic nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
Vehicle
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
After icv administration of KP-10, the percentages of OXT-ir neurons expressing FOS were remarkably higher in the SON and PVN than for vehicle treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255610
10AnimalAnimal study (in vivo)Mechanism
In male rats, icv KP-10 raised the percentage of oxytocin neurons expressing Fos in the paraventricular nucleus compared with vehicle.
In plain wordsIn rats, kisspeptin‑10 injected into the brain activated more oxytocin neurons in the paraventricular nucleus than vehicle did.
Peptide
Kisspeptin-10
Outcome
IncreaseFos in oxytocin neurons, paraventricular nucleus
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
Vehicle
Outcome group
Appetite and food intake · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
After icv administration of KP-10, the percentages of OXT-ir neurons expressing FOS were remarkably higher in the SON and PVN than for vehicle treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
Report a problemFND-3056255611

Studies that did not test the peptide alone3

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

11AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, pretreatment with antisense RNA against nucleobindin-2 significantly attenuated the decrease in food intake induced by KP-10.
In plain wordsIn rats, blocking nucleobindin-2 weakened the appetite-lowering effect of kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseKP-10-induced anorexia after nucleobindin-2 antisense RNA
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
KP-10 without antisense RNA
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
The decreased food intake induced by KP-10 was significantly attenuated by pretreatment with the icv administration of antisense RNA against nucleobindin-2.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3056255609
12AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, pretreatment with an oxytocin receptor antagonist partially abolished the anorexia induced by KP-10.
In plain wordsIn rats, blocking the oxytocin receptor partly removed the appetite-lowering effect of kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseKP-10-induced anorexia after oxytocin receptor antagonist
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
KP-10 without antagonist
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
The KP-10-induced anorexia was partially abolished by pretreatment with OXT receptor antagonist (OXTR-A).
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3056255612
13AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, oxytocin receptor antagonist pretreatment decreased the percentage of nesfatin-1 neurons expressing Fos in the arcuate nucleus.
In plain wordsIn rats, blocking the oxytocin receptor lowered the activation of nesfatin-1 neurons in the arcuate nucleus.
Peptide
Kisspeptin-10
Outcome
DecreaseFos in arcuate nesfatin-1 neurons after oxytocin receptor antagonist
Study
ratn: not reported in source
Male rats, intracerebroventricular injection
Comparator
KP-10 without antagonist
Outcome group
Appetite and food intake · Nervous system and cognition
Source sentences
Summary
The percentage of nesfatin-1-ir neurons expressing Fos-ir in the ARC was also decreased by OXTR-A pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
We examined the effects of the intracerebroventricular (icv) administration of KP-10 on feeding and nesfatin-1-immunoreactive (ir) or OXT-ir neurons in the rat hypothalamus, using Fos double immunohistochemistry in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-3056255613

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 2
9 Oct 2026, 03:04 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

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