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Study · In vitro (cells) · rat · 2019

7 results

Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity.

Saba J, Carniglia L, Ramírez D, Turati J, Imsen M, Durand D, Lasaga M, Caruso C

Molecular and cellular neurosciences4 Dec 2018Cited by 11 (Europe PMC)

PMID30529228 (opens in a new tab)DOI10.1016/j.mcn.2018.12.002 (opens in a new tab)PepBankPUB-30529228
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In rat striatal ST14A cells with normal huntingtin (Q15), NDP-MSH protected the cells from death caused by 3-nitropropionic acid.

    In plain wordsIn rat brain cells with normal huntingtin, NDP-MSH protected the cells from death caused by a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseCell death from 3-nitropropionic acid in Q15 cells
    Study

    ratn: not reported in source

    ST14A striatal cells expressing normal huntingtin (Q15) exposed to 3-NP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH protected Q15 cells, astrocytes and BV2 cells from death by 3-NP whereas it did not fully protect Q120 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In primary cultured astrocytes, NDP-MSH protected the cells from death caused by 3-nitropropionic acid.

    In plain wordsIn cultured astrocytes, NDP-MSH protected the cells from death caused by a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseAstrocyte death from 3-nitropropionic acid
    Study

    n: not reported in source

    Primary cultured astrocytes exposed to 3-NP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH protected Q15 cells, astrocytes and BV2 cells from death by 3-NP whereas it did not fully protect Q120 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In BV2 cells, NDP-MSH protected the cells from death caused by 3-nitropropionic acid.

    In plain wordsIn BV2 cells, NDP-MSH protected the cells from death caused by a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseBV2 cell death from 3-nitropropionic acid
    Study

    n: not reported in source

    BV2 cells exposed to 3-NP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH protected Q15 cells, astrocytes and BV2 cells from death by 3-NP whereas it did not fully protect Q120 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In rat striatal ST14A cells with mutant huntingtin (Q120), NDP-MSH did not fully protect the cells from 3-nitropropionic acid.

    In plain wordsIn rat brain cells with mutant huntingtin, NDP-MSH did not fully protect the cells from a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    MixedCell death from 3-nitropropionic acid in Q120 cells
    Study

    ratn: not reported in source

    ST14A striatal cells expressing mutant huntingtin (Q120) exposed to 3-NP
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NDP-MSH protected Q15 cells, astrocytes and BV2 cells from death by 3-NP whereas it did not fully protect Q120 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  5. 05LabIn vitro (cells)Mechanism

    In Q15 cells and astrocytes, the protection by NDP-MSH against 3-NP was blocked by the MC4R inhibitor JKC-363 and by the PPAR-gamma antagonist GW9662.

    In plain wordsIn cells, blocking MC4R or PPAR-gamma removed the protection that NDP-MSH gave against a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBlock of NDP-MSH protection by MC4R and PPAR-gamma inhibitors
    Study

    n: not reported in source

    Q15 cells and astrocytes exposed to 3-NP
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Protection of Q15 cells and astrocytes was blocked by a MC4R specific inhibitor (JKC-363) and a PPAR-γ antagonist (GW9662).
    2 context sentences
    Summary · context
    NDP-MSH protected Q15 cells, astrocytes and BV2 cells from death by 3-NP
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  6. 06LabIn vitro (cells)Mechanism

    In astrocytes, the BDNF receptor antagonist ANA-12 abolished the protection by NDP-MSH against 3-NP.

    In plain wordsIn cultured astrocytes, blocking the BDNF receptor removed the protection that NDP-MSH gave against a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBlock of NDP-MSH protection in astrocytes by BDNF receptor antagonist
    Study

    n: not reported in source

    Astrocytes exposed to 3-NP
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The BDNF receptor antagonist (ANA-12) abolished NDP-MSH protective effect in astrocytes but not in Q15 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.
  7. 07LabIn vitro (cells)Mechanism

    In Q15 cells, the BDNF receptor antagonist ANA-12 did not abolish the protection by NDP-MSH against 3-NP.

    In plain wordsIn rat brain cells with normal huntingtin, blocking the BDNF receptor did not remove the protection that NDP-MSH gave against a toxin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeEffect of BDNF receptor antagonist on NDP-MSH protection in Q15 cells
    Study

    ratn: not reported in source

    Q15 cells exposed to 3-NP
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The BDNF receptor antagonist (ANA-12) abolished NDP-MSH protective effect in astrocytes but not in Q15 cells.
    1 context sentence
    Summary · context
    3-nitropropionic acid (3-NP), which is known to induce striatal degeneration, was used to induce cell death in the rat striatal cell line ST14A expressing mutant human huntingtin (Q120) or in ST14A cells expressing normal human huntingtin (Q15), in primary cultured astrocytes, and in BV2 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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