Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury.

Wang X, Liu X, Zhao Y, Sun H, Wang Y

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie30 Nov 2018Cited by 7 (Europe PMC)

PMID30508736DOI10.1016/j.biopha.2018.11.059PepBankPUB-30508736

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In mouse epidermal stem cells, HNG suppressed UV-B-induced reactive oxygen species production.
In plain wordsIn cells, HNG reduced the harmful oxygen molecules that UV-B light produced in mouse skin stem cells.
Peptide
Humanin
Outcome
DecreaseUV-B-induced ROS production
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Oxidative stress · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
We show that HNG suppresses UV-B-induced ROS production and increases antioxidant glutathione expression.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873601
02LabIn vitro (cells)Mechanism
In mouse epidermal stem cells, HNG increased expression of the antioxidant glutathione.
In plain wordsIn cells, HNG raised expression of the antioxidant glutathione in mouse skin stem cells.
Peptide
Humanin
Outcome
IncreaseGlutathione expression
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Oxidative stress · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
increases antioxidant glutathione expression.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873602
03LabIn vitro (cells)Efficacy outcome
In mouse epidermal stem cells, HNG pretreatment limited the production of TNF-α, IL-1β and IL-6 after UV-B exposure.
In plain wordsIn cells, HNG pretreatment kept inflammatory signals low in mouse skin stem cells after UV-B light.
Peptide
Humanin
Outcome
DecreaseUV-B-induced cytokine production (TNF-α, IL-1β, IL-6)
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Inflammation markers · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
HNG-pretreated cells exhibit very mild production of cytokines, including TNF-α, IL-1β, and IL-6, upon exposure to UV-B.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873603
04LabIn vitro (cells)Efficacy outcome
In mouse epidermal stem cells, HNG pretreatment protected against UV-B-mediated cytotoxicity.
In plain wordsIn cells, HNG pretreatment protected mouse skin stem cells from damage by UV-B light.
Peptide
Humanin
Outcome
DecreaseUV-B-mediated cytotoxicity
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Cell viability and death · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
HNG pretreatment is protective against UV-B-mediated cytotoxicity and promotes ESC survival.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873604
05LabIn vitro (cells)Efficacy outcome
In mouse epidermal stem cells exposed to UV-B, HNG pretreatment promoted cell survival.
In plain wordsIn cells, HNG pretreatment helped mouse skin stem cells survive UV-B light.
Peptide
Humanin
Outcome
IncreaseEpidermal stem cell survival
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Cell viability and death · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
HNG pretreatment is protective against UV-B-mediated cytotoxicity and promotes ESC survival.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873605
06LabIn vitro (cells)Efficacy outcome
In mouse epidermal stem cells, HNG attenuated the UV-B-induced reduction in mitochondrial membrane potential.
In plain wordsIn cells, HNG limited the loss of mitochondrial membrane potential that UV-B light caused in mouse skin stem cells.
Peptide
Humanin
Outcome
IncreaseUV-B-induced reduction in mitochondrial membrane potential
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Mitochondrial function · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
Moreover, HNG treatment attenuates the UV-B-induced reduction in mitochondrial membrane potential (MMP) and preserves their identity and stem cell capacity.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873606
07LabIn vitro (cells)Efficacy outcome
In mouse epidermal stem cells exposed to UV-B, HNG treatment preserved stem cell identity and capacity.
In plain wordsIn cells, HNG treatment kept the identity and stem cell capacity of mouse skin stem cells after UV-B light.
Peptide
Humanin
Outcome
IncreaseStem cell identity and capacity
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Cell viability and death · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
preserves their identity and stem cell capacity.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873607
08LabIn vitro (cells)Mechanism
In mouse epidermal stem cells, HNG ameliorated the UV-B-induced reduction in Wnt/β-catenin pathway proteins Wtn3a, Myc and cyclin D1.
In plain wordsIn cells, HNG limited the UV-B-induced drop in Wnt/β-catenin pathway proteins in mouse skin stem cells.
Peptide
Humanin
Outcome
IncreaseWnt/β-catenin pathway proteins (Wtn3a, Myc, cyclin D1)
Study
mousen: not reported in source
Primary mouse epidermal stem cells exposed to UV-B
Comparator
UV-B without HNG
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
Mechanistically, HNG treatment ameliorates the UV-B-induced reduction in Wnt/β-catenin pathway proteins, including Wtn3a, Myc, and cyclin D1.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment.
Report a problemFND-3050873608

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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