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Study · Measured the body's own peptide · 2019

9 results

Follicular fluid humanin concentration is related to ovarian reserve markers and clinical pregnancy after IVF-ICSI: a pilot study.

Rao M, Zhou F, Tang L, Zeng Z, Hu S, Wang Y, Ke D, Cheng G, Xia W, Zhang L, Zhu C

Reproductive biomedicine online23 Nov 2018Cited by 25 (Europe PMC)

PMID30503199 (opens in a new tab)DOI10.1016/j.rbmo.2018.11.002 (opens in a new tab)PepBankPUB-30503199
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In follicular fluid from 179 patients undergoing IVF or ICSI, humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    In plain wordsIn women having IVF or ICSI, the body's own humanin in follicular fluid ranged from 86.40 to 417.60 pg/ml.

    Peptide
    Humanin
    Outcome
    Not applicableFollicular fluid humanin concentration
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Follicular fluid humanin concentration
    86.4 to 417.6 pg/ml
    IVF/ICSI patients

    Source sentences

    Summary
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Follicular fluid humanin concentrations correlated negatively with FSH levels in patients undergoing IVF or ICSI.

    In plain wordsIn IVF patients, higher natural humanin in follicular fluid was linked to lower FSH.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin correlation with FSH
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    −0.21 r
    FSH

    Source sentences

    Summary
    FSH (r = -0.21; P < 0.01)
    1 context sentence
    Summary · context
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    Follicular fluid humanin concentrations correlated negatively with LH levels in patients undergoing IVF or ICSI.

    In plain wordsIn IVF patients, higher natural humanin in follicular fluid was linked to lower LH.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin correlation with LH
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    −0.18 r
    LH

    Source sentences

    Summary
    LH (r = -0.18; P = 0.02)
    1 context sentence
    Summary · context
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Follicular fluid humanin concentrations correlated positively with antral follicle count in patients undergoing IVF or ICSI.

    In plain wordsIn IVF patients, higher natural humanin in follicular fluid was linked to a higher antral follicle count.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin correlation with antral follicle count
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    0.27 r
    antral follicle count

    Source sentences

    Summary
    antral follicle count (r = 0.27; P < 0.01)
    1 context sentence
    Summary · context
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    Follicular fluid humanin concentrations correlated positively with anti-Müllerian hormone levels in patients undergoing IVF or ICSI.

    In plain wordsIn IVF patients, higher natural humanin in follicular fluid was linked to higher anti-Müllerian hormone.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin correlation with anti-Müllerian hormone
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    0.24 r
    anti-Müllerian hormone

    Source sentences

    Summary
    anti-Müllerian hormone (r = 0.24; P = 0.03)
    1 context sentence
    Summary · context
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    Follicular fluid humanin concentrations correlated positively with inhibin B levels in patients undergoing IVF or ICSI.

    In plain wordsIn IVF patients, higher natural humanin in follicular fluid was linked to higher inhibin B.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin correlation with inhibin B
    Study

    n = 179

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Correlation coefficient
    0.46 r
    inhibin B

    Source sentences

    Summary
    inhibin B (r = 0.46; P < 0.01)
    1 context sentence
    Summary · context
    Follicular fluid humanin concentrations ranged from 86.40 to 417.60 pg/ml.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    In ovarian tissue from two patients, strong expression of the body's own humanin was found in granulosa cells, oocytes and stromal cells.

    In plain wordsIn ovary tissue from two patients, the body's own humanin was found in several ovarian cell types.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin localization in ovarian tissue
    Study

    n = 2

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Strong humanin expression was found in the granulosa cells, oocytes and stromal cells of the ovary.
    1 context sentence
    Summary · context
    Ovarian tissues were collected from two patients undergoing surgery for ovarian cysts.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    Rich humanin mRNA expression was found in human granulosa cells.

    In plain wordsHuman ovarian granulosa cells made the message for the body's own humanin.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin mRNA in granulosa cells
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    RT-PCR product length
    119 bp
    granulosa cells

    Source sentences

    Summary
    Agarose gel electrophoresis of RT-PCR products showed rich humanin mRNA expression in human granulosa cells (119 bp).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  9. 09HumanEndogenous levelObservational studyOther

    In patients undergoing IVF or ICSI, those in the highest quartile of follicular fluid humanin (Q4) were more likely to achieve a pregnancy than those in the lowest (Q1).

    In plain wordsIn IVF patients, women with the highest natural humanin in follicular fluid were more likely to become pregnant than those with the lowest.

    Peptide
    Humanin
    Outcome
    IncreaseClinical pregnancy by humanin quartile
    Study

    n: not reported in source

    Comparator
    Quartile 1
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Odds ratio
    3.6 ratio
    Q4 vs Q1
    95% CI
    1.09 to 11.84 ratio
    Q4 vs Q1

    Source sentences

    Summary
    Patients in Q4 were more likely to achieve a pregnancy than Q1 (OR = 3.60; 95% CI 1.09 to 11.84).
    1 context sentence
    Summary · context
    Patients were subdivided into four groups according to follicular fluid humanin concentration quartiles (Q1-Q4).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownPhase not statedNCT04104958

IVF Outcome in Polycystic Ovary Syndrome Patients

Assiut Universityn = 100est. 1 Mar 2020 to est. 15 Feb 2021

Polycystic Ovary Syndrome

Trial pageClinicalTrials.govUpdated 10 Jan 2020

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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