Skip to content

Study · Animal study (in vivo) · rat · 2020

5 results

Effect of amylin on memory and central insulin resistance in a rat model of Alzheimer's disease.

Nassar SZ, Badae NM, Issa YA

Archives of physiology and biochemistry17 Nov 2018Cited by 21 (Europe PMC)

PMID30449203 (opens in a new tab)DOI10.1080/13813455.2018.1534244 (opens in a new tab)PepBankPUB-30449203
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with STZ-induced Alzheimer's disease, pramlintide improved learning and memory.

    In plain wordsIn rats with induced Alzheimer's disease, pramlintide improved learning and memory.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseLearning and memory
    Study

    ratn: not reported in source

    Streptozotocin-induced Alzheimer's disease
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    200 μg/kg/day · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus.
    2 context sentences
    Summary · context
    Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg).
    Summary · context
    Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with STZ-induced Alzheimer's disease, pramlintide enhanced insulin signalling (p-IR and p-PI3K).

    In plain wordsIn rats with induced Alzheimer's disease, pramlintide enhanced insulin signalling.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseInsulin signalling
    Study

    ratn: not reported in source

    Streptozotocin-induced Alzheimer's disease
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    200 μg/kg/day · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus.
    2 context sentences
    Summary · context
    Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg).
    Summary · context
    Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with STZ-induced Alzheimer's disease, pramlintide lowered CSF glucose.

    In plain wordsIn rats with induced Alzheimer's disease, pramlintide lowered glucose in cerebrospinal fluid.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseCSF glucose
    Study

    ratn: not reported in source

    Streptozotocin-induced Alzheimer's disease
    Outcome group
    Glycemic control · Nervous system and cognition
    Studied dose
    200 μg/kg/day · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus.
    2 context sentences
    Summary · context
    Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg).
    Summary · context
    Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with STZ-induced Alzheimer's disease, pramlintide lowered phosphorylated tau proteins.

    In plain wordsIn rats with induced Alzheimer's disease, pramlintide lowered phosphorylated tau proteins.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreasePhosphorylated tau
    Study

    ratn: not reported in source

    Streptozotocin-induced Alzheimer's disease
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 μg/kg/day · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus.
    2 context sentences
    Summary · context
    Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg).
    Summary · context
    Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with STZ-induced Alzheimer's disease, pramlintide lowered hippocampal amyloid-β peptide.

    In plain wordsIn rats with induced Alzheimer's disease, pramlintide lowered amyloid-beta in the hippocampus.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseHippocampal amyloid-β
    Study

    ratn: not reported in source

    Streptozotocin-induced Alzheimer's disease
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    200 μg/kg/day · 5 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both Pramlintide and Metformin improve learning and memory through enhancing insulin signalling (p-IR and p-PI3K) which lead to lowering level of CSF glucose, phosphorylated tau proteins, and amyloid-β peptide (Aβ) in hippocampus.
    2 context sentences
    Summary · context
    Alzheimer's disease (AD) was induced in albino rats by intracerebroventricular injection of STZ (3 mg/kg).
    Summary · context
    Rats received either amylin analogue (Pramlintide 200 μg/kg/day) or Metformin (30 mg/kg/day) for 5 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.