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Study · Animal study (in vivo) · pig · 2019

5 results

Local Thymosin β4 Gel Injection Prevents Esophageal Stricture after Circumferential Endoscopic Submucosal Dissection in a Porcine Model.

Wang H, Shuai Q, Tang J, Long D, Xu C, Liu F, Li ZS

Digestive diseases (Basel, Switzerland)14 Nov 2018Cited by 9 (Europe PMC)

PMID30428463 (opens in a new tab)DOI10.1159/000492216 (opens in a new tab)PepBankPUB-30428463
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs after circumferential endoscopic submucosal dissection, local Tβ4 gel injection shortened the resolution of the esophageal stricture compared with control.

    In plain wordsIn pigs, thymosin beta‑4 gel injected locally shortened the time for a food pipe narrowing to resolve compared with controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTime to resolution of esophageal stricture
    Study

    pign = 8

    Bama pigs, porcine circumferential ESD esophageal stricture
    Comparator
    Control group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · local injectionAs given in this study (pig).

    Source sentences

    Summary
    Local Tβ4 gel injection has shortened resolution of the stricture (p = 0.012) and was associated with a lesser number of EBD sessions (p = 0.002).
    2 context sentences
    Summary · context
    A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group).
    Summary · context
    Local injection of Tβ4 gel was administered in the experimental group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs after circumferential endoscopic submucosal dissection, local Tβ4 gel injection was associated with fewer endoscopic balloon dilation sessions than control.

    In plain wordsIn pigs, thymosin beta‑4 gel was linked to fewer balloon stretching procedures than in controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNumber of balloon dilation sessions
    Study

    pign = 8

    Bama pigs, porcine circumferential ESD esophageal stricture
    Comparator
    Control group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · local injectionAs given in this study (pig).

    Source sentences

    Summary
    Local Tβ4 gel injection has shortened resolution of the stricture (p = 0.012) and was associated with a lesser number of EBD sessions (p = 0.002).
    2 context sentences
    Summary · context
    A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group).
    Summary · context
    Local injection of Tβ4 gel was administered in the experimental group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs after circumferential endoscopic submucosal dissection, esophageal stricture was milder in the Tβ4 gel group than in the control group.

    In plain wordsIn pigs, the food pipe narrowing was milder with thymosin beta‑4 gel than in controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSeverity of esophageal stricture
    Study

    pign = 8

    Bama pigs, porcine circumferential ESD esophageal stricture
    Comparator
    Control group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · local injectionAs given in this study (pig).

    Source sentences

    Summary
    The severity of esophageal stricture was milder in the experimental group (p = 0.046 vs. control group).
    2 context sentences
    Summary · context
    A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group).
    Summary · context
    Local injection of Tβ4 gel was administered in the experimental group.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs after circumferential endoscopic submucosal dissection, esophageal stricture developed in all pigs, including those given Tβ4 gel.

    In plain wordsIn pigs, the food pipe narrowing still developed in all animals, including those given thymosin beta‑4 gel.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeOccurrence of esophageal stricture
    Study

    pign = 8

    Bama pigs, porcine circumferential ESD esophageal stricture
    Comparator
    Control group
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · local injectionAs given in this study (pig).

    Source sentences

    Summary
    Esophageal stricture developed after circumferential ESD in all pigs.
    2 context sentences
    Summary · context
    A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group).
    Summary · context
    Local injection of Tβ4 gel was administered in the experimental group.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In pigs after circumferential endoscopic submucosal dissection, no adverse events occurred in the study.

    In plain wordsIn pigs, no side effects were reported in the study.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeAdverse events
    Study

    pign = 8

    Bama pigs, porcine circumferential ESD esophageal stricture
    Comparator
    Control group
    Outcome group
    Adverse events · Gastrointestinal
    Studied dose
    Dose not stated · local injectionAs given in this study (pig).

    Source sentences

    Summary
    No adverse events occurred in the study.
    2 context sentences
    Summary · context
    A total of 8 Bama pigs underwent esophageal circumferential ESD under anesthesia (n = 4 for experimental and control group).
    Summary · context
    Local injection of Tβ4 gel was administered in the experimental group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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