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Study · Animal study (in vivo) · rat · 2018

9 results

Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats.

Mirzakhani N, Farshid AA, Tamaddonfard E, Imani M, Erfanparast A, Noroozinia F

Life sciences1 Nov 2018Cited by 23 (Europe PMC)

PMID30391465 (opens in a new tab)DOI10.1016/j.lfs.2018.10.043 (opens in a new tab)PepBankPUB-30391465
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine accelerated sciatic functional index recovery.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine accelerated functional recovery.

    Peptide
    L-carnosine
    Outcome
    IncreaseSciatic functional index recovery
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 mg/kg · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Carnosine at the doses of 20 and 40 mg/kg accelerated SFI recovery.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine accelerated sciatic functional index recovery.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine accelerated functional recovery.

    Peptide
    L-carnosine
    Outcome
    IncreaseSciatic functional index recovery
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    40 mg/kg · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Carnosine at the doses of 20 and 40 mg/kg accelerated SFI recovery.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine improved Wallerian degeneration severity.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine reduced degeneration severity.

    Peptide
    L-carnosine
    Outcome
    DecreaseWallerian degeneration severity
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Wallerian degeneration severity and myelinated fibers density, myelin sheath thickness and diameter as well as ultrastructural changes of myelinated axons were improved.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine improved myelinated fiber density; the abstract did not state its direction.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine improved myelinated fiber density; the abstract did not state its direction.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMyelinated fiber density
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Wallerian degeneration severity and myelinated fibers density, myelin sheath thickness and diameter as well as ultrastructural changes of myelinated axons were improved.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine improved myelin sheath thickness; the abstract did not state its direction.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine improved myelin sheath thickness; the abstract did not state its direction.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMyelin sheath thickness
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Wallerian degeneration severity and myelinated fibers density, myelin sheath thickness and diameter as well as ultrastructural changes of myelinated axons were improved.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine improved myelin sheath diameter; the abstract did not state its direction.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine improved myelin sheath diameter; the abstract did not state its direction.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMyelin sheath diameter
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Wallerian degeneration severity and myelinated fibers density, myelin sheath thickness and diameter as well as ultrastructural changes of myelinated axons were improved.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine improved myelinated axon ultrastructure.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine improved the fine structure of myelinated axons.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMyelinated axon ultrastructure
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Wallerian degeneration severity and myelinated fibers density, myelin sheath thickness and diameter as well as ultrastructural changes of myelinated axons were improved.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, carnosine reversed injury-induced nerve biochemical changes in MDA, SOD and TNF-α.

    In plain wordsIn rats with sciatic nerve crush injury, carnosine reversed injury-related nerve biochemical changes in MDA, SOD and TNF-α.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedNerve biochemical changes in MDA, SOD and TNF-α
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    It also recovered nerve tissue biochemical (MDA, SOD and TNF-α) changes induced by crush injury.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with sciatic nerve crush injury, muscle weight ratio reached near-normal values after carnosine treatment.

    In plain wordsIn rats with sciatic nerve crush injury, muscle weight ratio reached near-normal values after carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedMuscle weight ratio
    Study

    ratsn: not reported in source

    Sciatic nerve crush injury
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · 15 consecutive daysAs given in this study (rats).

    Source sentences

    Summary
    Muscle weight ratio was reached to near normal values.
    3 context sentences
    Summary · context
    Seventy-two rats were divided into six groups including control, sham, crush and carnosine (10, 20 and 40 mg/kg) groups.
    Summary · context
    Crush injury in left sciatic nerve was induced by a small haemostatic forceps.
    Summary · context
    Carnosine was administered for 15 consecutive days after induction of crush injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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