Study · Animal study (in vivo) · bos taurus (holstein) and bos indicus (gyr) prepubertal heifers · 2019

7 results

Profile of LH release in response to intramuscular treatment with kisspeptin in Bos indicus and Bos taurus prepubertal heifers.

Macedo GG, Mingoti RD, Batista EOS, Monteiro BM, Vieira LM, Barletta RV, Wiltbank MC, Nogueira GP, Rennó FP, Maio JR, Baruselli PS

Theriogenology19 Oct 2018Cited by 6 (Europe PMC)

PMID30390480DOI10.1016/j.theriogenology.2018.10.011PepBankPUB-30390480

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal Holstein and Gyr heifers, all animals responded to the intramuscular treatments, including kisspeptin‑10, with an LH surge.
In plain wordsIn young heifers, injected kisspeptin‑10 caused a surge of LH.
Peptide
Kisspeptin-10
Outcome
IncreaseLH surge after kisspeptin-10
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn = 48
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
All animals responded to the treatments with an LH surge (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048001
02AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers given the treatments, Holstein heifers had a greater induced LH area under the curve than Gyr heifers.
In plain wordsIn young heifers, Holstein animals showed a larger induced LH response than Gyr animals.
Peptide
Kisspeptin-10
Outcome
IncreaseBreed difference in induced LH area under the curve
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn = 48
Comparator
Gyr heifers
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
There was an effect of breed (P < 0.01) on induced LH release, with Holstein heifers having a greater area under the curve for LH (AUC; P < 0.01) and greater LH peak amplitude (P < 0.01) than Gyr heifers.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048006
03AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers given the treatments, Holstein heifers had a greater induced LH peak amplitude than Gyr heifers.
In plain wordsIn young heifers, Holstein animals showed a higher induced LH peak than Gyr animals.
Peptide
Kisspeptin-10
Outcome
IncreaseBreed difference in induced LH peak amplitude
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn = 48
Comparator
Gyr heifers
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
There was an effect of breed (P < 0.01) on induced LH release, with Holstein heifers having a greater area under the curve for LH (AUC; P < 0.01) and greater LH peak amplitude (P < 0.01) than Gyr heifers.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048007
04AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers of both breeds, the kisspeptin‑10 μg/kg group had a greater LH area under the curve.
In plain wordsIn young heifers, the highest kisspeptin dose gave a larger LH response.
Peptide
Kisspeptin-10
Outcome
IncreaseLH area under the curve at the highest kisspeptin dose
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
10 μg/kg · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
Nevertheless, greater AUC for LH occurred in Kp10 heifers for both breeds.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048002
05AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers of both breeds, kisspeptin produced an earlier LH peak than the GnRH agonist.
In plain wordsIn young heifers, the LH peak came earlier with kisspeptin than with the GnRH agonist.
Peptide
Kisspeptin-10
Outcome
DecreaseTime to LH peak versus GnRH agonist
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn: not reported in source
Comparator
GnRH agonist (buserelin acetate)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
For both breeds, heifers treated with Kp displayed an earlier (P < 0.01) LH peak with a reduced amplitude of the LH peak (P < 0.01) and reduced LH AUC (P < 0.01) compared to heifers treated with GnRH agonist.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048003
06AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers of both breeds, kisspeptin produced a smaller LH peak amplitude than the GnRH agonist.
In plain wordsIn young heifers, kisspeptin gave a smaller LH peak than the GnRH agonist.
Peptide
Kisspeptin-10
Outcome
DecreaseLH peak amplitude versus GnRH agonist
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn: not reported in source
Comparator
GnRH agonist (buserelin acetate)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
For both breeds, heifers treated with Kp displayed an earlier (P < 0.01) LH peak with a reduced amplitude of the LH peak (P < 0.01) and reduced LH AUC (P < 0.01) compared to heifers treated with GnRH agonist.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048004
07AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal heifers of both breeds, kisspeptin produced a smaller LH area under the curve than the GnRH agonist.
In plain wordsIn young heifers, kisspeptin gave a smaller total LH response than the GnRH agonist.
Peptide
Kisspeptin-10
Outcome
DecreaseLH area under the curve versus GnRH agonist
Study
Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifersn: not reported in source
Comparator
GnRH agonist (buserelin acetate)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2.5, 5.0 and 10 μg/kg body weight · intramuscularAs given in this study (Bos taurus (Holstein) and Bos indicus (Gyr) prepubertal heifers).
Source sentences
Summary
For both breeds, heifers treated with Kp displayed an earlier (P < 0.01) LH peak with a reduced amplitude of the LH peak (P < 0.01) and reduced LH AUC (P < 0.01) compared to heifers treated with GnRH agonist.
2 context sentences(design, population, supporting numbers)
Summary · context
Holstein heifers weighing 215.1 ± 38.6 kg (n = 24; aged 5-8 mo) and Gyr heifers weighing 215.4 ± 31.4 kg (n = 24; aged 6-10 mo) were enrolled in this study.
Summary · context
For each genetic group, heifers were randomly assigned to one of four treatments: Kp at 2.5 μg/kg body weight (Kp2.5), Kp at 5.0 μg/kg (Kp5), Kp at 10 μg/kg (Kp10), or gonadotropin-releasing hormone (GnRH) agonist (0.01 mg of buserelin acetate per heifer), all administered by I.M. injection.
Report a problemFND-3039048005

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Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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