Skip to content

Study · Not a test of the peptide alone · 2018

3 results

Synthesis and Biological Activity of Thymosin β4-Anionic Boron Cluster Conjugates.

Fink K, Kobak K, Kasztura M, Boratyński J, Goszczyński TM

Bioconjugate chemistry30 Oct 2018Cited by 12 (Europe PMC)

PMID30365887 (opens in a new tab)DOI10.1021/acs.bioconjchem.8b00646 (opens in a new tab)PepBankPUB-30365887
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Activity measurement

    In H9C2 cardiomyocytes, thymosin beta‑4 boron cluster conjugates retained or improved the prosurvival activity of thymosin beta‑4.

    In plain wordsIn heart muscle cells, thymosin beta‑4 linked to boron clusters kept or improved its pro-survival effect.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedProsurvival activity toward cardiomyocytes
    Study

    n: not reported in source

    H9C2 cardiomyocyte cell line
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    We obtained conjugates with dramatically different stabilities (τ1/2 from 3-836 h (Tβ4-[B12H12]2- conjugates) and 9-1329 h (Tβ4-[COSAN]- conjugates)) while retaining or improving the prosurvival activity of Tβ4 toward cardiomyocytes (H9C2 cell line).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Thymosin beta‑4 conjugates with the dodecaborate anion had very different stabilities, with half-lives from 3 to 836 h.

    In plain wordsIn lab tests, thymosin beta‑4 linked to a boron cluster broke down at very different speeds depending on the link site.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableHydrolysis half-life of thymosin beta-4-[B12H12] conjugates
    Study

    n: not reported in source

    Chemical hydrolysis of ester bonds
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    tau1/2
    3 to 836 h
    Tβ4-[B12H12]2- conjugates

    Source sentences

    Summary
    We obtained conjugates with dramatically different stabilities (τ1/2 from 3-836 h (Tβ4-[B12H12]2- conjugates) and 9-1329 h (Tβ4-[COSAN]- conjugates)) while retaining or improving the prosurvival activity of Tβ4 toward cardiomyocytes (H9C2 cell line).
    1 context sentence
    Summary · context
    The ester bonds in the conjugates undergo hydrolysis at different rates depending on the site of the modification.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Other

    Thymosin beta‑4 conjugates with cobalt bis(1,2-dicarbollide) had very different stabilities, with half-lives from 9 to 1329 h.

    In plain wordsIn lab tests, thymosin beta‑4 linked to a cobalt boron cluster broke down at very different speeds depending on the link site.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableHydrolysis half-life of thymosin beta-4-COSAN conjugates
    Study

    n: not reported in source

    Chemical hydrolysis of ester bonds
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    tau1/2
    9 to 1329 h
    Tβ4-COSAN conjugates

    Source sentences

    Summary
    We obtained conjugates with dramatically different stabilities (τ1/2 from 3-836 h (Tβ4-[B12H12]2- conjugates) and 9-1329 h (Tβ4-[COSAN]- conjugates)) while retaining or improving the prosurvival activity of Tβ4 toward cardiomyocytes (H9C2 cell line).
    1 context sentence
    Summary · context
    The ester bonds in the conjugates undergo hydrolysis at different rates depending on the site of the modification.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.