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Study · Animal study (in vivo) · wistar rats · 2018

2 results

Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine.

Fedorova TN, Devyatov AA, Berezhnoi DS, Stvolinskii SL, Morozova MP, Gavrilova SA, Tutelyan VA

Bulletin of experimental biology and medicine23 Oct 2018Cited by 8 (Europe PMC)

PMID30353340 (opens in a new tab)DOI10.1007/s10517-018-4256-x (opens in a new tab)PepBankPUB-30353340
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with focal ischemia, low-dose carnosine had an oxidative-status protective effect comparable to high-dose carnosine.

    In plain wordsIn rats with focal ischemia, low-dose carnosine protected oxidative status comparably to high-dose carnosine.

    Peptide
    L-carnosine
    Outcome
    Not applicableOxidative status at low versus high dose
    Study

    Wistar ratsn: not reported in source

    Focal cerebral ischemia
    Comparator
    500 mg/kg carnosine
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    50 mg/kgAs given in this study (Wistar rats).

    Source sentences

    Summary
    We demonstrated for the first time a neuroprotective effect of therapeutic administration of carnosine in low doses (50 mg/kg) on parameters of the oxidative status under conditions of focal ischemia comparable to its effect of high doses (500 mg/kg) as well as its local effect in the penumbra zone.
    1 context sentence
    Summary · context
    Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats with focal ischemia, carnosine showed a dose-dependent effect on penumbra antioxidant activity; direction was not stated.

    In plain wordsIn rats with focal ischemia, carnosine affected penumbra antioxidant activity with dose; the abstract did not state the direction.

    Peptide
    L-carnosine
    Outcome
    Direction not reportedPenumbra antioxidant activity dose response
    Study

    Wistar ratsn: not reported in source

    Focal cerebral ischemia
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A dose-dependent effect of carnosine on antioxidant activity in the penumbra zone during ischemia was also demonstrated.
    1 context sentence
    Summary · context
    Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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