Glucagon-like peptide-2 reduces the obesity-associated inflammation in the brain.

Nuzzo D, Baldassano S, Amato A, Picone P, Galizzi G, Caldara GF, Di Carlo M, Mulè F

Neurobiology of disease19 Oct 2018Cited by 33 (Europe PMC)

PMID30347266DOI10.1016/j.nbd.2018.10.012PepBankPUB-30347266

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In obese mice, teduglutide significantly attenuated HFD-induced marker expression increases compared with untreated HFD mice.
In plain wordsIn obese mice, teduglutide reduced inflammation and stress marker increases compared with untreated HFD mice.
Peptide
Teduglutide
Outcome
DecreaseInflammation and stress marker expression
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Untreated high-fat diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
[Gly²]-GLP-2 treatment significantly attenuated the HFD-induced increased expression of the various markers, as well as the higher levels of reactive oxygen species found in brains of untreated-HFD mice.
2 context sentences(design, population, supporting numbers)
Summary · context
HFD feeding increased the expression of pro-inflammatory mediators (NF-kB, IL-8, TNF-α, IL-1β and IL-6), glial fibrillary acidic protein (GFAP), index of gliosis and neurodegeneration, stress marker proteins (p-ERK, Hsp60 and i-NOS), amyloid-β precursor protein (APP).
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726601
02AnimalAnimal study (in vivo)Efficacy outcome
In obese mice, teduglutide significantly attenuated elevated brain reactive oxygen species compared with untreated HFD mice.
In plain wordsIn obese mice, teduglutide reduced brain reactive oxygen species compared with untreated HFD mice.
Peptide
Teduglutide
Outcome
DecreaseReactive oxygen species
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Untreated high-fat diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
[Gly²]-GLP-2 treatment significantly attenuated the HFD-induced increased expression of the various markers, as well as the higher levels of reactive oxygen species found in brains of untreated-HFD mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726602
03AnimalAnimal study (in vivo)Efficacy outcome
In obese mice, cortical GFAP increases were less prominent with teduglutide than in untreated HFD mice.
In plain wordsIn obese mice, brain GFAP increases were smaller with teduglutide than in untreated HFD mice.
Peptide
Teduglutide
Outcome
DecreaseCortical GFAP immunofluorescence
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Untreated high-fat diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Immunofluorescence confirmed that the increase of GFAP or APP in the brain cortex of HFD mice were less prominent in the [Gly²]-GLP-2 treated group.
1 context sentence(design, population, supporting numbers)
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726603
04AnimalAnimal study (in vivo)Efficacy outcome
In obese mice, cortical APP increases were less prominent with teduglutide than in untreated HFD mice.
In plain wordsIn obese mice, brain APP increases were smaller with teduglutide than in untreated HFD mice.
Peptide
Teduglutide
Outcome
DecreaseCortical APP immunofluorescence
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Untreated high-fat diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Immunofluorescence confirmed that the increase of GFAP or APP in the brain cortex of HFD mice were less prominent in the [Gly²]-GLP-2 treated group.
1 context sentence(design, population, supporting numbers)
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726604
05AnimalAnimal study (in vivo)Efficacy outcome
In obese mice, teduglutide significantly reduced TUNEL-positive brain cell numbers compared with untreated HFD mice.
In plain wordsIn obese mice, teduglutide reduced dying brain cell numbers compared with untreated HFD mice.
Peptide
Teduglutide
Outcome
DecreaseTUNEL-positive brain cells
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Untreated high-fat diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
TUNEL-positive cell number in brain sections of [Gly²]-GLP-2-treated HFD-fed mice was significantly lesser in comparison with untreated-HFD animals and similar to STD fed mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726605
06AnimalAnimal study (in vivo)Efficacy outcome
In obese mice given teduglutide, TUNEL-positive brain cell numbers were similar to those in standard-diet-fed mice.
In plain wordsIn obese mice given teduglutide, dying brain cell numbers were similar to those in standard-diet-fed mice.
Peptide
Teduglutide
Outcome
No significant changeTUNEL-positive brain cells
Study
mousen: not reported in source
High-fat diet-fed obese mice
Comparator
Standard-diet-fed mice
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
TUNEL-positive cell number in brain sections of [Gly²]-GLP-2-treated HFD-fed mice was significantly lesser in comparison with untreated-HFD animals and similar to STD fed mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly²]-GLP-2 (teduglutide), the stable analogue of the GLP-2, and they were compared to age-matched untreated obese and lean animals.
Report a problemFND-3034726606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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