Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility.

Xue H, Liu M, Hao W, Li Y

Pakistan journal of medical sciences1 Sept 2018Cited by 9 (Europe PMC)

PMID30344551PMCIDPMC6191787DOI10.12669/pjms.345.15574PepBankPUB-30344551

Summary

ObjectiveTo investigate the effects of laparoscopic surgery combined with triptorelin acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility.MethodsIn this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group. Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.ResultsThe success rate of pregnancy in group A was higher than that in group B and C. The incidence of adverse pregnancy outcome was lower than that in group B and C. Kupperman score and subjective symptom score were lower than those in group B and C before treatment. Sex hormone level and CA125 level were significantly better. In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar.ConclusionLaparoscopic surgery combined with GnRH-a can improve the success and good rate of pregnancy in EMT patients, reduce clinical symptoms, avoid long-term recurrence, and increase the risk of adverse reactions. Triptorelin acetate is superior to gestrinone and mifepristone.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility after laparoscopy, pregnancy success was higher with triptorelin than gestrinone.
In plain wordsAfter laparoscopy for endometriosis and infertility, pregnancy success was higher with triptorelin than gestrinone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePregnancy success rate
Study
n = 100
Comparator
Gestrinone after laparoscopy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The success rate of pregnancy in group A was higher than that in group B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455101
02HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility after laparoscopy, pregnancy success was higher with triptorelin than mifepristone.
In plain wordsAfter laparoscopy for endometriosis and infertility, pregnancy success was higher with triptorelin than mifepristone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePregnancy success rate
Study
n = 100
Comparator
Mifepristone after laparoscopy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The success rate of pregnancy in group A was higher than that in group B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455102
03HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility, long-term recurrence was lower with triptorelin than gestrinone.
In plain wordsIn women with endometriosis and infertility, long-term recurrence was lower with triptorelin than gestrinone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLong-term recurrence
Study
n = 100
Comparator
Gestrinone after laparoscopy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455107
04HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility, long-term recurrence was lower with triptorelin than mifepristone.
In plain wordsIn women with endometriosis and infertility, long-term recurrence was lower with triptorelin than mifepristone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLong-term recurrence
Study
n = 100
Comparator
Mifepristone after laparoscopy
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455108
05HumanRandomized controlled trialSafety outcome
In women with endometriosis and infertility, adverse reaction incidence was similar with triptorelin and gestrinone.
In plain wordsIn women with endometriosis and infertility, adverse reaction incidence was similar with triptorelin and gestrinone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeAdverse reaction incidence
Study
n = 100
Comparator
Gestrinone after laparoscopy
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455109
06HumanRandomized controlled trialSafety outcome
In women with endometriosis and infertility, adverse reaction incidence was similar with triptorelin and mifepristone.
In plain wordsIn women with endometriosis and infertility, adverse reaction incidence was similar with triptorelin and mifepristone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeAdverse reaction incidence
Study
n = 100
Comparator
Mifepristone after laparoscopy
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455110
07HumanRandomized controlled trialSafety outcome
In women with endometriosis and infertility after laparoscopy, adverse pregnancy outcomes were less frequent with triptorelin than gestrinone.
In plain wordsAfter laparoscopy for endometriosis and infertility, adverse pregnancy outcomes were less frequent with triptorelin than gestrinone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAdverse pregnancy outcome
Study
n: not reported in source
Comparator
Gestrinone after laparoscopy
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The incidence of adverse pregnancy outcome was lower than that in group B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455103
08HumanRandomized controlled trialSafety outcome
In women with endometriosis and infertility after laparoscopy, adverse pregnancy outcomes were less frequent with triptorelin than mifepristone.
In plain wordsAfter laparoscopy for endometriosis and infertility, adverse pregnancy outcomes were less frequent with triptorelin than mifepristone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAdverse pregnancy outcome
Study
n: not reported in source
Comparator
Mifepristone after laparoscopy
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The incidence of adverse pregnancy outcome was lower than that in group B and C.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group.
Summary · context
Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455104
09HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility, the abstract reports significantly better sex hormone levels with triptorelin without specifying direction.
In plain wordsIn women with endometriosis and infertility, the abstract reports better sex hormone levels with triptorelin but does not specify direction.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedSex hormone level
Study
n: not reported in source
Comparator
Groups B and C and pretreatment values
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Sex hormone level and CA125 level were significantly better. In the B and C groups and before treatment;
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group. Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455105
10HumanRandomized controlled trialEfficacy outcome
In women with endometriosis and infertility, the abstract reports significantly better CA125 levels with triptorelin without specifying direction.
In plain wordsIn women with endometriosis and infertility, the abstract reports better CA125 levels with triptorelin but does not specify direction.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedCA125 level
Study
n: not reported in source
Comparator
Groups B and C and pretreatment values
Outcome group
Cancer biomarkers and prognosis · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
Sex hormone level and CA125 level were significantly better. In the B and C groups and before treatment;
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group. Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery.
Show in the study text Report a problemFND-3034455106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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