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Study · Animal study (in vivo) · zebrafish · 2018

2 results

Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges.

Sardela VF, Anselmo CS, Nunes IKDC, Carneiro GRA, Dos Santos GRC, de Carvalho AR, Labanca BJ, Silva Oliveira D, Ribeiro WD, de Araujo ALD, Padilha MC, de Lima CKF and 4 more

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de Sousa VP, de Aquino Neto FR, Gualberto Pereira HM, Gualberto Pereira HM

Drug testing and analysis22 Nov 2018Cited by 19 (Europe PMC)

PMID30341930 (opens in a new tab)DOI10.1002/dta.2523 (opens in a new tab)PepBankPUB-30341930
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In a zebrafish water tank model, hexarelin was metabolized very fast.

    In plain wordsIn zebrafish tank tests, hexarelin broke down very fast.

    Peptide
    Hexarelin
    Outcome
    Not applicableMetabolization rate in zebrafish water tank
    Study

    zebrafishn: not reported in source

    Zebrafish water tank (ZWT)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    hexarelin displays a very fast metabolization in ZWT conditions and all the metabolites described for human were observed in ZWT.
    2 context sentences
    Summary · context
    Finally, hexarelin was used as a model to evaluate studies by ZWT for drugs with low stability.
    Summary · context
    Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In a zebrafish water tank model, all hexarelin metabolites described for humans were observed.

    In plain wordsIn zebrafish tank tests, hexarelin produced all of the breakdown products that earlier work had described for it.

    Peptide
    Hexarelin
    Outcome
    Not applicableOverlap of metabolites with human metabolites
    Study

    zebrafishn: not reported in source

    Zebrafish water tank (ZWT)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    all the metabolites described for human were observed in ZWT.
    2 context sentences
    Summary · context
    Finally, hexarelin was used as a model to evaluate studies by ZWT for drugs with low stability.
    Summary · context
    Zebrafish (Danio rerio) water tank (ZWT) approach was investigated as an alternative model for metabolism studies based on six different experiments with four model compounds.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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