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Study · Animal study (in vivo) · rat · 2019

8 results

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome.

Liang H, Gao J, Zhang C, Li C, Wang Q, Fan J, Wu Z, Wang Q

Toxicology and applied pharmacology4 Oct 2018Cited by 27 (Europe PMC)

PMID30292833 (opens in a new tab)DOI10.1016/j.taap.2018.10.006 (opens in a new tab)PepBankPUB-30292833
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN alleviated bone injuries.

    In plain wordsIn rats exposed to aluminum, NMN reduced bone injury.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBone injuries
    Study

    ratn: not reported in source

    Aluminum-induced bone injury
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    We orally exposed AlCl3 (10 mg/L) to Sprague-Dawley rats in drinking water for 12 weeks while NMN (20 mg/kg) were intraperitoneally injected in last 4 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aluminum-exposed rats, NMN decreased bone loss.

    In plain wordsIn rats exposed to aluminum, NMN reduced bone loss.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBone loss
    Study

    ratn: not reported in source

    Aluminum-induced bone injury
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    We orally exposed AlCl3 (10 mg/L) to Sprague-Dawley rats in drinking water for 12 weeks while NMN (20 mg/kg) were intraperitoneally injected in last 4 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aluminum-exposed rats, NMN suppressed oxidative stress.

    In plain wordsIn rats exposed to aluminum, NMN reduced oxidative stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    ratn: not reported in source

    Aluminum-induced bone injury
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    20 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    We orally exposed AlCl3 (10 mg/L) to Sprague-Dawley rats in drinking water for 12 weeks while NMN (20 mg/kg) were intraperitoneally injected in last 4 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aluminum-exposed rats, NMN inhibited the TXNIP-NLRP3 inflammasome pathway.

    In plain wordsIn rats exposed to aluminum, NMN inhibited the TXNIP-NLRP3 inflammatory pathway.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTXNIP-NLRP3 pathway
    Study

    ratn: not reported in source

    Aluminum-induced bone injury
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    20 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    We orally exposed AlCl3 (10 mg/L) to Sprague-Dawley rats in drinking water for 12 weeks while NMN (20 mg/kg) were intraperitoneally injected in last 4 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In aluminum-exposed rats, NMN inhibited pro-inflammatory cytokine production.

    In plain wordsIn rats exposed to aluminum, NMN reduced inflammatory cytokine production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePro-inflammatory cytokine production
    Study

    ratn: not reported in source

    Aluminum-induced bone injury
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    20 mg/kg · intraperitoneal · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    We orally exposed AlCl3 (10 mg/L) to Sprague-Dawley rats in drinking water for 12 weeks while NMN (20 mg/kg) were intraperitoneally injected in last 4 weeks.
  6. 06LabIn vitro (cells)Mechanism

    In aluminum-treated cells, NMN suppressed oxidative stress.

    In plain wordsIn cells treated with aluminum, NMN reduced oxidative stress.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative stress
    Study

    n: not reported in source

    Al-treated MC3T3-E1 cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    Meanwhile, treatment with TXNIP siRNA performed the same protective effects as NMN in Al-treated MC3T3-E1 cells.
  7. 07LabIn vitro (cells)Mechanism

    In aluminum-treated cells, NMN inhibited the TXNIP-NLRP3 inflammasome pathway.

    In plain wordsIn cells treated with aluminum, NMN inhibited the TXNIP-NLRP3 inflammatory pathway.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseTXNIP-NLRP3 pathway
    Study

    n: not reported in source

    Al-treated MC3T3-E1 cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    Meanwhile, treatment with TXNIP siRNA performed the same protective effects as NMN in Al-treated MC3T3-E1 cells.
  8. 08LabIn vitro (cells)Mechanism

    In aluminum-treated cells, NMN inhibited pro-inflammatory cytokine production.

    In plain wordsIn cells treated with aluminum, NMN reduced inflammatory cytokine production.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreasePro-inflammatory cytokine production
    Study

    n: not reported in source

    Al-treated MC3T3-E1 cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, NMN treatment significantly alleviated Al-induced bone injuries by decreasing bone loss, suppressing oxidative stress as well as inhibiting Thioredoxin-interacting protein (TXNIP)-NLRP3 inflammasome pathway and pro-inflammatory cytokine production in vivo and in vitro.
    1 context sentence
    Summary · context
    Meanwhile, treatment with TXNIP siRNA performed the same protective effects as NMN in Al-treated MC3T3-E1 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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