In a receptor assay, blunt snout bream MC5R (MamMC5R) had the highest affinity for NDP-MSH, ahead of alpha-MSH and beta-MSH.
In plain wordsIn lab tests, a fish melanocortin-5 receptor bound NDP-MSH more strongly than alpha-MSH or beta-MSH.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- Not applicableBinding affinity of NDP-MSH for blunt snout bream MC5R
- Study
n: not reported in source
MamMC5R receptor binding and signaling assay- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
The results revealed that MamMC5R had the highest affinity for NDP-MSH, followed by α- and β-MSH.
1 context sentence(design, population, supporting numbers)
With human MC5R (HsaMC5R) as a control, several agonists including α-melanocyte-stimulating hormone (α-MSH), and β-MSH in addition to an analogue [Nle4, D-Phe7]-α-MSH (NDP-MSH), were used to investigate the binding and signaling properties of MamMC5R.