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Study · Animal study (in vivo) · mouse · 2018

4 results

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D and 7 more

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Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P

Scientific reports21 Sept 2018Cited by 83 (Europe PMC)

PMID30242290 (opens in a new tab)PMCIDPMC6154958 (opens in a new tab)DOI10.1038/s41598-018-32616-7 (opens in a new tab)PepBankPUB-30242290
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Summary

Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neurodegenerative disease. Here we demonstrate that humanin administration has neuroprotective effects in vitro in human cell culture models and is sufficient to improve cognition in vivo in aged mice. Furthermore, in a human cohort, using mitochondrial GWAS, we identified a specific SNP (rs2854128) in the humanin-coding region of the mitochondrial genome that is associated with a decrease in circulating humanin levels. In a large, independent cohort, consisting of a nationally-representative sample of older adults, we find that this SNP is associated with accelerated cognitive aging, supporting the concept that humanin is an important factor in cognitive aging.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, humanin administration improved cognition.

    In plain wordsIn aged mice, humanin improved cognition.

    Peptide
    Humanin
    Outcome
    IncreaseCognition in aged mice
    Study

    mousen: not reported in source

    aged mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    is sufficient to improve cognition in vivo in aged mice.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human cell culture models, humanin administration had neuroprotective effects.

    In plain wordsIn human cells grown in the lab, humanin showed protective effects on nerve cells.

    Peptide
    Humanin
    Outcome
    Direction not reportedNeuroprotection in human cell culture
    Study

    humann: not reported in source

    human cell culture models
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    humanin administration has neuroprotective effects in vitro in human cell culture models

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03HumanEndogenous levelObservational studyOther

    In a human cohort, the SNP rs2854128 in the humanin-coding region of the mitochondrial genome was associated with lower circulating humanin levels.

    In plain wordsIn a human cohort, a variant in the humanin gene was linked to lower levels of the body's own humanin.

    Peptide
    Humanin
    Outcome
    DecreaseCirculating humanin level by SNP rs2854128
    Study

    n: not reported in source

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    in a human cohort, using mitochondrial GWAS, we identified a specific SNP (rs2854128) in the humanin-coding region of the mitochondrial genome that is associated with a decrease in circulating humanin levels.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 04HumanNot a test of Humanin aloneObservational studyOther

    In a nationally-representative sample of older adults, the SNP rs2854128 was associated with accelerated cognitive aging.

    In plain wordsIn older adults, a variant in the humanin gene was linked to faster cognitive aging.

    Peptide
    Humanin
    Outcome
    IncreaseCognitive aging by SNP rs2854128
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Aging and longevity

    Source sentences

    Summary
    we find that this SNP is associated with accelerated cognitive aging

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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