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Study · In vitro (cells) · 2018

3 results

Thymosin β4 promotes glucose-impaired endothelial progenitor cell function via Akt/endothelial nitric oxide synthesis signaling pathway.

Qiu F, Song J, Bi X, Wang M, Zhao Y, Fu G

Experimental and therapeutic medicine10 Aug 2018Cited by 2 (Europe PMC)

PMID30233693 (opens in a new tab)PMCIDPMC6143828 (opens in a new tab)DOI10.3892/etm.2018.6593 (opens in a new tab)PepBankPUB-30233693
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human endothelial progenitor cells, thymosin beta‑4 reversed the suppression of cell function by high glucose.

    In plain wordsIn human cells grown in lab dishes, thymosin beta‑4 reversed the harm that high glucose did to progenitor cell function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseGlucose-impaired EPC function
    Study

    humann: not reported in source

    Endothelial progenitor cells from healthy volunteers, high glucose
    Comparator
    High glucose without thymosin beta-4
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Functional studies showed that high concentrations of glucose significantly suppressed EPC function, while this adverse effect was reversed by the administration of Tβ4.
    2 context sentences
    Summary · context
    EPCs were isolated from the peripheral blood of healthy volunteers and formed a cobblestone shape after 3-4 weeks of cultivation.
    Summary · context
    Then, EPCs were treated with high concentrations of glucose (25 mM) for 4 days and administrated with Tβ4 for further study.
  2. 02LabIn vitro (cells)Mechanism

    In high-glucose human endothelial progenitor cells, Akt siRNA reduced the protective effect of thymosin beta‑4 on cell function.

    In plain wordsIn cells, silencing Akt weakened the protection that thymosin beta‑4 gave to progenitor cell function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseProtective effect of thymosin beta-4 with Akt siRNA
    Study

    humann: not reported in source

    Endothelial progenitor cells from healthy volunteers, high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Akt small interfering (si)RNA and eNOS siRNA were demonstrated to reduce the protective effect of Tβ4 against glucose-impaired EPC functions.
    2 context sentences
    Summary · context
    EPCs were isolated from the peripheral blood of healthy volunteers and formed a cobblestone shape after 3-4 weeks of cultivation.
    Summary · context
    Then, EPCs were treated with high concentrations of glucose (25 mM) for 4 days and administrated with Tβ4 for further study.
  3. 03LabIn vitro (cells)Mechanism

    In high-glucose human endothelial progenitor cells, eNOS siRNA reduced the protective effect of thymosin beta‑4 on cell function.

    In plain wordsIn cells, silencing eNOS weakened the protection that thymosin beta‑4 gave to progenitor cell function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseProtective effect of thymosin beta-4 with eNOS siRNA
    Study

    humann: not reported in source

    Endothelial progenitor cells from healthy volunteers, high glucose
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Akt small interfering (si)RNA and eNOS siRNA were demonstrated to reduce the protective effect of Tβ4 against glucose-impaired EPC functions.
    2 context sentences
    Summary · context
    EPCs were isolated from the peripheral blood of healthy volunteers and formed a cobblestone shape after 3-4 weeks of cultivation.
    Summary · context
    Then, EPCs were treated with high concentrations of glucose (25 mM) for 4 days and administrated with Tβ4 for further study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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